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Found 1202 of ic50 for UniProtKB: Q92847
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50292221((S)-3-(2,4-Dichloro-phenyl)-1-(2-diethylamino-ethy...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047485(CHEMBL3319217)
Affinity DataIC50:  0.0780nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50267262(CHEMBL501253)
Affinity DataIC50:  0.0800nMAssay Description:Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50267261(CHEMBL525994)
Affinity DataIC50:  0.120nMAssay Description:Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50422313(CHEMBL2310891)
Affinity DataIC50:  0.120nMAssay Description:Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50366689(GHRELIN)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047481(CHEMBL3319221)
Affinity DataIC50:  0.150nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50422316(CHEMBL2310888)
Affinity DataIC50:  0.160nMAssay Description:Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19386(2,4-diaminopyrimidine derivative, 8b | 6-[(benzylo...)
Affinity DataIC50:  0.200nM EC50:  5.80nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50379328(CHEMBL2011825)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066086(1N-{6-[1'-[2-(1-amino-1-methylethylcarboxamido)-3-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory concentration of the compound (biotinylated probe) is evaluated for [35S]- MK-0677 bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50094223(CHEMBL3586033)
Affinity DataIC50:  0.230nMAssay Description:Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50292225((S)-3-(2,5-Dichloro-phenyl)-1-(2-diethylamino-ethy...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047429(CHEMBL3319398)
Affinity DataIC50:  0.240nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM21940(Ghrelin)
Affinity DataIC50:  0.25nMAssay Description:Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50366689(GHRELIN)
Affinity DataIC50:  0.25nMAssay Description:Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047480(CHEMBL3319222)
Affinity DataIC50:  0.290nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19387(2,4-diaminopyrimidine derivative, 8c | 6-[(benzylo...)
Affinity DataIC50:  0.300nM EC50:  7.20nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19331(CHEMBL266063 | N-[(1R)-2-(1H-indol-3-yl)-1-{5-[2-(...)
Affinity DataIC50:  0.300nM EC50:  3nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected LLC cells with 125I-His9-ghrelin in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19331(CHEMBL266063 | N-[(1R)-2-(1H-indol-3-yl)-1-{5-[2-(...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19331(CHEMBL266063 | N-[(1R)-2-(1H-indol-3-yl)-1-{5-[2-(...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096216(CHEMBL3593636)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19387(2,4-diaminopyrimidine derivative, 8c | 6-[(benzylo...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human GHS receptor by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047431(CHEMBL3319397)
Affinity DataIC50:  0.310nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047482(CHEMBL3319220)
Affinity DataIC50:  0.310nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047483(CHEMBL3319219)
Affinity DataIC50:  0.330nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50366689(GHRELIN)
Affinity DataIC50:  0.390nMAssay Description:Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096217(CHEMBL3593632)
Affinity DataIC50:  0.390nMAssay Description:Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047688(CHEMBL3319407)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181184(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-6-((3-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human GHS receptor by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50181180(CHEMBL377514 | N-(3,5-dimethylbenzyl)-3-(5-(4-(4-(...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human GHS receptor by binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049478(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of the compound against human growth hormone secretagogue (GHS) receptorMore data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50267264(CHEMBL504776)
Affinity DataIC50:  0.420nMAssay Description:Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096220(CHEMBL3593635)
Affinity DataIC50:  0.420nMAssay Description:Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047426(CHEMBL3319400)
Affinity DataIC50:  0.430nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096215(CHEMBL3593815)
Affinity DataIC50:  0.440nMAssay Description:Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047474(CHEMBL3319228)
Affinity DataIC50:  0.480nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19333(N-[(1R)-1-{4-[(2,4-dimethoxyphenyl)methyl]-5-[2-(1...)
Affinity DataIC50:  0.5nM EC50:  0.600nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected LLC cells with 125I-His9-ghrelin in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049478(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)
Affinity DataIC50:  0.510nMAssay Description:Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsMore data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047475(CHEMBL3319227)
Affinity DataIC50:  0.530nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047428(CHEMBL3319399)
Affinity DataIC50:  0.570nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19331(CHEMBL266063 | N-[(1R)-2-(1H-indol-3-yl)-1-{5-[2-(...)
Affinity DataIC50:  0.600nMAssay Description:Displacement of 125I-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19332(N-[(1R)-2-(1H-indol-3-yl)-1-{4-[(4-methoxyphenyl)m...)
Affinity DataIC50:  0.600nM EC50:  1.60nMAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected LLC cells with 125I-His9-ghrelin in the presence of increasing co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM102975(US8546435, 3)
Affinity DataIC50:  0.600nMAssay Description:Competitive binding assay using ghrelin receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047432(CHEMBL3319396)
Affinity DataIC50:  0.620nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049478(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)
Affinity DataIC50:  0.630nMAssay Description:Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed ...More data for this Ligand-Target Pair
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047478(CHEMBL3319225)
Affinity DataIC50:  0.670nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047479(CHEMBL3319224)
Affinity DataIC50:  0.690nMAssay Description:Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50089878(CHEMBL3581030)
Affinity DataIC50:  0.700nMAssay Description:Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50232281((R)-N-((4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-t...)
Affinity DataIC50:  0.700nMAssay Description:Displacement of 125I-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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