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Found 109 of ic50 for UniProtKB: P16232
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50174298(3-(4-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)bicy...)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018759(CHEMBL3291350)
Affinity DataIC50:  4nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50435691(CHEMBL2391968)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018761(CHEMBL3291348)
Affinity DataIC50:  5nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50340378(3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1...)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50433411(CHEMBL2380648)
Affinity DataIC50:  7nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50611946(HSD-016 | Hsd-016)
Affinity DataIC50:  8nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50433412(CHEMBL2380649)
Affinity DataIC50:  9nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50340386(3-(4-(ethylsulfonylmethyl)bicyclo[2.2.2]octan-1-yl...)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018760(CHEMBL3291357)
Affinity DataIC50:  10nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018797(CHEMBL3291345)
Affinity DataIC50:  10nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018793(CHEMBL3291344)
Affinity DataIC50:  12nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018769(CHEMBL3291346)
Affinity DataIC50:  13nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50252367(1-[3-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]...)
Affinity DataIC50:  13nMAssay Description:Inhibition of rat 11betaHSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM340822(US9765040, Compound 14)
Affinity DataIC50:  16nMAssay Description:The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018794(CHEMBL3291340)
Affinity DataIC50:  16nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50433405(CHEMBL2380642)
Affinity DataIC50:  16nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50433408(CHEMBL2380645)
Affinity DataIC50:  18nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018795(CHEMBL3291339)
Affinity DataIC50:  18nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018799(CHEMBL3291347)
Affinity DataIC50:  18nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018803(CHEMBL3291358)
Affinity DataIC50:  21nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50433410(CHEMBL2380647)
Affinity DataIC50:  21nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018798(CHEMBL3291342)
Affinity DataIC50:  22nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM340823(US9765040, Compound 15)
Affinity DataIC50:  23nMAssay Description:The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50433407(CHEMBL2380644)
Affinity DataIC50:  24nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM340790(US9765040, Compound 3)
Affinity DataIC50:  24nMAssay Description:The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM340798(US9765040, Compound 9)
Affinity DataIC50:  26nMAssay Description:The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50433404(CHEMBL2380641)
Affinity DataIC50:  28nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50334684(((1R)-4-(N-cyclopropyl-4-((S)-1,1,1-trifluoro-2-hy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of rat 11beta-HSD1 assessed as inhibition of conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50294783(3,3-Dimethyl-pentanedioic acid(5-carbamoyl-adamant...)
Affinity DataIC50:  31nMAssay Description:Inhibition of 11beta-HSD1 in rat liver microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM340791(US9765040, Compound 4)
Affinity DataIC50:  32nMAssay Description:The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM340796(US9765040, Compound 7)
Affinity DataIC50:  32nMAssay Description:The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018806(CHEMBL3291343)
Affinity DataIC50:  35nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM340548(US9765040, Compound 1)
Affinity DataIC50:  35nMAssay Description:The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018802(CHEMBL3291354)
Affinity DataIC50:  39nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50436987(CHEMBL2402470)
Affinity DataIC50:  39nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018807(CHEMBL3291355)
Affinity DataIC50:  41nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50252244((2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-meth...)
Affinity DataIC50:  42nMAssay Description:Inhibition of rat 11betaHSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM340642(US9765040, Compound 2)
Affinity DataIC50:  52nMAssay Description:The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50448696(CHEMBL3127869)
Affinity DataIC50:  55nMAssay Description:Inhibition of rat 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM340803(US9765040, Compound 11)
Affinity DataIC50:  64nMAssay Description:The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50433409(CHEMBL2380646)
Affinity DataIC50:  65nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM340814(US9765040, Compound 13)
Affinity DataIC50:  68nMAssay Description:The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50433402(CHEMBL2380639)
Affinity DataIC50:  70nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM340797(US9765040, Compound 8)
Affinity DataIC50:  70nMAssay Description:The procedure for measuring the 11β-HSD1-inhibitory activity is as follows. The enzyme reaction and the measurement were carried out using a 384...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50018809(CHEMBL3291356)
Affinity DataIC50:  77nMAssay Description:Inhibition of rat 11betaHSD1 assessed as reduction of cortisone to cortisol by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50252438((2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-meth...)
Affinity DataIC50:  81nMAssay Description:Inhibition of rat 11betaHSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50016983(CHEMBL3220543)
Affinity DataIC50:  82nMAssay Description:Inhibition of N-terminal His-tagged full length rat 11beta-HSD1 assessed as inhibition of cortisone to cortisol conversion preincubated for 25 mins m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50399335(CHEMBL2177609)
Affinity DataIC50:  86nMAssay Description:Inhibition of N-terminal 6-His tagged full length rat 11betaHSD1 incubated for 25 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50334675(((1R)-4-(N-cyclopropyl-4-((S)-1,1,1-trifluoro-2-hy...)
Affinity DataIC50:  86nMAssay Description:Inhibition of rat 11beta-HSD1 assessed as inhibition of conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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