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Found 105 of ec50 for UniProtKB: O88871
TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360710(US9828381, 5-1)
Affinity DataEC50:  3nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360708(US9828381, 4-1)
Affinity DataEC50:  5nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360711(US9828381, 5-2)
Affinity DataEC50:  7nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360706(US9828381, 3-1)
Affinity DataEC50:  8nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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LigandPNGBDBM24195(3-aminopropylphosphinic derivative, (R)-7 | AZD335...)
Affinity DataKi:  5.10nM ΔG°:  -11.2kcal/mole EC50:  8.64nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360709(US9828381, 4-2)
Affinity DataEC50:  9nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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LigandPNGBDBM24198(3-aminopropylphosphinic derivative, (R)-8 | [(2R)-...)
Affinity DataKi:  4.30nM ΔG°:  -11.3kcal/mole EC50:  14nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360707(US9828381, 3-2)
Affinity DataEC50:  14nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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LigandPNGBDBM24193((3-amino-2-fluoropropyl)phosphinic acid | 3-aminop...)
Affinity DataKi:  10nM ΔG°:  -10.8kcal/mole EC50:  15nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24184((3-aminopropyl)phosphinic acid | 3-aminopropylphos...)
Affinity DataKi:  15nM ΔG°:  -10.6kcal/mole EC50:  19nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24196((3-amino-2-fluoropropyl)(methyl)phosphinic acid | ...)
Affinity DataKi:  14nM ΔG°:  -10.6kcal/mole EC50:  23nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24185((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...)
Affinity DataKi:  33nM ΔG°:  -10.1kcal/mole EC50:  41nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360693(US9828381, 2-11)
Affinity DataEC50:  57nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360704(US9828381, 2-22)
Affinity DataEC50:  70nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360690(US9828381, 2-8)
Affinity DataEC50:  71nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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LigandPNGBDBM24191((3-amino-2-oxopropyl)phosphinic acid | (3-amino-2-...)
Affinity DataKi:  48nM ΔG°:  -9.88kcal/mole EC50:  81nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
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In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360717(US9828381, 8-2)
Affinity DataEC50:  87nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360702(US9828381, 2-20)
Affinity DataEC50:  93nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360683(US9828381, 2-1)
Affinity DataEC50:  118nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360686(US9828381, 2-4)
Affinity DataEC50:  128nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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LigandPNGBDBM24186((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...)
Affinity DataKi:  50nM ΔG°:  -9.85kcal/mole EC50:  130nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360687(US9828381, 2-5)
Affinity DataEC50:  146nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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LigandPNGBDBM24189(3-aminopropylphosphinic derivative, (R)-4 | 3-amin...)
Affinity DataKi:  180nM ΔG°:  -9.10kcal/mole EC50:  150nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360692(US9828381, 2-10)
Affinity DataEC50:  152nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360696(US9828381, 2-14)
Affinity DataEC50:  165nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360689(US9828381, 2-7)
Affinity DataEC50:  185nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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LigandPNGBDBM24186((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...)
Affinity DataKi:  94nM ΔG°:  -9.48kcal/mole EC50:  220nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360688(US9828381, 2-6)
Affinity DataEC50:  242nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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LigandPNGBDBM24194(3-aminopropylphosphinic derivative, (S)-7 | [(2S)-...)
Affinity DataKi:  70nM ΔG°:  -9.66kcal/mole EC50:  250nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24192((3-amino-2-oxopropyl)(methyl)phosphinic acid | (3-...)
Affinity DataKi:  200nM ΔG°:  -9.04kcal/mole EC50:  270nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360734(US9828381, 8-19)
Affinity DataEC50:  274nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360724(US9828381, 8-9)
Affinity DataEC50:  344nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360720((3R)-1-(5-methyl-2-{1-[4-(trifluoromethyl)phenyl]e...)
Affinity DataEC50:  365nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360727(US9828381, 8-12)
Affinity DataEC50:  370nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360726(US9828381, 8-11)
Affinity DataEC50:  378nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360703(US9828381, 2-21)
Affinity DataEC50:  394nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360718(US9828381, 8-3)
Affinity DataEC50:  420nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360684(US9828381, 2-2)
Affinity DataEC50:  435nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360695(US9828381, 2-13)
Affinity DataEC50:  446nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360700(US9828381, 2-18)
Affinity DataEC50:  499nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360735(US9828381, 8-20)
Affinity DataEC50:  500nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360685(US9828381, 2-3)
Affinity DataEC50:  508nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360721(US9828381, 8-6)
Affinity DataEC50:  509nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360736(US9828381, 8-21)
Affinity DataEC50:  561nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360730(US9828381, 8-15)
Affinity DataEC50:  570nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360698(US9828381, 2-16)
Affinity DataEC50:  586nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360729(US9828381, 8-14)
Affinity DataEC50:  593nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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LigandPNGBDBM24189(3-aminopropylphosphinic derivative, (R)-4 | 3-amin...)
Affinity DataKi:  840nM ΔG°:  -8.20kcal/mole EC50:  600nMpH: 7.4 T: 2°CAssay Description:Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360691(US9828381, 2-9)
Affinity DataEC50:  604nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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TargetGamma-aminobutyric acid type B receptor subunit 2(Rattus norvegicus)
Abbvie Deutschland

US Patent
LigandPNGBDBM360741(US9828381, 9-4)
Affinity DataEC50:  628nMAssay Description:The composition of the assay mixtures [in a final volume of 200 μL in 96-well U-bottom plates (Greiner) was as follows: 50 mM Tris-HCl buffer, p...More data for this Ligand-Target Pair
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