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Found 117 of ic50 for UniProtKB: P04775
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051090(CHEMBL3318149)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051091(CHEMBL3318150)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051089(CHEMBL3318148)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051075(CHEMBL3318134)
Affinity DataIC50:  8nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051088(CHEMBL3318147)
Affinity DataIC50:  8nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Na+ influx in chinese hamster ovary cells expressing rat brain sodium channel type IIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051077(CHEMBL3318136)
Affinity DataIC50:  24nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051084(CHEMBL3318143)
Affinity DataIC50:  28nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051079(CHEMBL3318138)
Affinity DataIC50:  33nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50118517(CHEMBL3617067)
Affinity DataIC50:  36nMAssay Description:Inhibition of rat NaV1.2 channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051082(CHEMBL3318141)
Affinity DataIC50:  45nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051076(CHEMBL3318135)
Affinity DataIC50:  45nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50262566((2S,3S)-3-[(1R)-6-Methoxy-1-methyl-1-trifluorometh...)
Affinity DataIC50:  48nMAssay Description:Displacement of [3H]batrachotoxinin from rat sodium channel type 2A subunit expressed in CHO-CNa2A cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051081(CHEMBL3318140)
Affinity DataIC50:  50nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051086(CHEMBL3318145)
Affinity DataIC50:  51nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066062(1,3-Bis-(4-sec-butyl-phenyl)-imidazolidin-2-yliden...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066059(1,3-Bis-(4-sec-butyl-phenyl)-tetrahydro-pyrimidin-...)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051083(CHEMBL3318142)
Affinity DataIC50:  63nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051080(CHEMBL3318139)
Affinity DataIC50:  98nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50:  105nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066417(CHEMBL112806 | N-(4-Benzyloxy-phenyl)-N'-(4-tert-b...)
Affinity DataIC50:  110nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066427(CHEMBL109210 | N,N'-Bis-(4-butyl-phenyl)-guanidine)
Affinity DataIC50:  130nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051087(CHEMBL3318146)
Affinity DataIC50:  138nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066420(CHEMBL112132 | N-(4-Benzyloxy-phenyl)-N'-(4-butyl-...)
Affinity DataIC50:  140nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066423(CHEMBL326502 | N,N'-Bis-(4-butoxy-phenyl)-guanidin...)
Affinity DataIC50:  190nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066066((S)-1-[4-(Benzothiazol-2-yl-methyl-amino)-piperidi...)
Affinity DataIC50:  260nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50019293(1-(1-{3-[Bis-(4-fluoro-phenyl)-amino]-propyl}-pipe...)
Affinity DataIC50:  340nMAssay Description:Inhibitory activity against type IIA sodium channel in CNaIIA-1 cell line expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051085(CHEMBL3318144)
Affinity DataIC50:  342nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50017702(1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...)
Affinity DataIC50:  420nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066425(CHEMBL112515 | N,N'-Bis-(4-phenoxy-phenyl)-guanidi...)
Affinity DataIC50:  430nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50010754(CHEMBL81626 | N,N'-Bis-(4-isopropyl-phenyl)-guanid...)
Affinity DataIC50:  460nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066067(2-(4-tert-Butyl-phenyl)-6-isopropyl-3,4-dihydro-2H...)
Affinity DataIC50:  460nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50017702(1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...)
Affinity DataIC50:  490nMAssay Description:Inhibitory activity against type IIA sodium channel in CNaIIA-1 cell line expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50117922((1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)...)
Affinity DataIC50:  500nMAssay Description:Inhibition of rat brain Nav1.2 expressed in HEK293 cells by whole cell voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051985(CHEMBL288826 | N-[3-(4-Benzyl-piperidin-1-yl)-prop...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against type IIA sodium channel in CNaIIA-1 cell line expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066069(CHEMBL103284 | N-(4-tert-Butyl-benzyl)-N-(4-sec-bu...)
Affinity DataIC50:  620nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066428(CHEMBL326774 | N-Acenaphthen-5-yl-N'-(4-sec-butyl-...)
Affinity DataIC50:  680nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051984(CHEMBL36637 | N-[3-(4-Benzyl-piperazin-1-yl)-propy...)
Affinity DataIC50:  700nMAssay Description:Inhibitory activity against type IIA sodium channel in CNaIIA-1 cell line expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051979(CHEMBL35818 | N-{3-[4-(2-Oxo-2,3-dihydro-benzoimid...)
Affinity DataIC50:  720nMAssay Description:Inhibitory activity against type IIA sodium channel in CNaIIA-1 cell line expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066052((3-sec-Butyl-phenyl)-[1-(4-sec-butyl-phenyl)-imida...)
Affinity DataIC50:  780nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066057(CHEMBL110909 | CHEMBL320199 | N,N'-Bis-(4-sec-buty...)
Affinity DataIC50:  800nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066057(CHEMBL110909 | CHEMBL320199 | N,N'-Bis-(4-sec-buty...)
Affinity DataIC50:  800nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066419(CHEMBL326741 | N,N'-Bis-(4-hexyl-phenyl)-guanidine)
Affinity DataIC50:  830nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066424(CHEMBL331126 | N,N'-Bis-(4-phenylsulfanyl-phenyl)-...)
Affinity DataIC50:  840nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066422(CHEMBL326130 | N,N'-Bis-biphenyl-4-yl-guanidine)
Affinity DataIC50:  850nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051078(CHEMBL3318137)
Affinity DataIC50:  919nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50066060(CHEMBL545504 | N,N'-Bis-(4-sec-butyl-phenyl)-N,N'-...)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051978(2,2-Diphenyl-N-[3-(4-phenyl-piperidin-1-yl)-propyl...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory activity against type IIA sodium channel in CNaIIA-1 cell line expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma

Curated by ChEMBL
LigandPNGBDBM50051968(CHEMBL37217 | N-[3-(Benzyl-methyl-amino)-propyl]-2...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibitory activity against type IIA sodium channel in CNaIIA-1 cell line expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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