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Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222640(CHEMBL415543)

IC50: 0.320nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222640(CHEMBL415543)

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222695(CHEMBL155433)

IC50: 0.460nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222637(CHEMBL154743)

IC50: 0.5nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222696(CHEMBL156041)

IC50: 0.550nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222635(CHEMBL267205)

IC50: 0.720nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50522021(CHEMBL4465116)

IC50: 0.730nMAssay Description:Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222647(CHEMBL154990)

IC50: 0.950nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222649(CHEMBL155730)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50521183(CHEMBL4461475 | US11260049, Ex. 125)

IC50: 1nMAssay Description:Antagonist activity at rat TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10 m...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50521996(CHEMBL4459940)

IC50: 1.10nMAssay Description:Inhibition of rat TRPV4 expressed in HEK293 cells assessed as reduction in Ca2+ influx incubated for 30 mins by Fluo4-AM dye basedMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222641(CHEMBL157962)

IC50: 1.20nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50502640(CHEMBL4470585)

IC50: 1.60nMAssay Description:Inhibition of rat TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye bas...More data for this Ligand-Target Pair

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3D Structure (crystal)

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232815(CHEMBL4104743)

IC50: 1.60nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232797(CHEMBL4073922)

IC50: 2nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50192809(CHEMBL3941914)

IC50: 2.10nMAssay Description:Antagonist activity at rat TRPV4 assessed as inhibition of hypotonicity-induced activationMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222638(CHEMBL422702)

IC50: 2.40nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232800(CHEMBL4103166)

IC50: 2.5nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232813(CHEMBL4097859)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232796(CHEMBL4094483)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232790(CHEMBL4084542)

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232804(CHEMBL4087716)

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222644(CHEMBL434295)

IC50: 2.5nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222648(CHEMBL156693)

IC50: 3nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222639(CHEMBL356682)

IC50: 3.20nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232799(CHEMBL4078886)

IC50: 3.20nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232803(CHEMBL4068023)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232809(CHEMBL4065154)

IC50: 4nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50505550(CHEMBL4439190 | US11260049, Ex. 2)

IC50: 4nMAssay Description:Antagonist activity at rat TRPV4 expressed in BHK/AC9 cells assessed as inhibition of GSK634775-induced calcium immobilization pre-incubated for 10 m...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232798(CHEMBL4095413)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50256209(CHEMBL4101768)

IC50: 4.40nMAssay Description:Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins fo...More data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222646(CHEMBL157917)

IC50: 5.10nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

CHEMBL PC cid PC sid

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50502650(CHEMBL4549613)

IC50: 5.5nMAssay Description:Inhibition of rat TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye bas...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232805(CHEMBL4069979)

IC50: 6nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222694(CHEMBL158189)

IC50: 6.10nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232791(CHEMBL4062863)

IC50: 8nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232802(CHEMBL4105593)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50256228(CHEMBL4099293)

IC50: 8.20nMAssay Description:Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins fo...More data for this Ligand-Target Pair

PC cid PC sid Similars

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50192809(CHEMBL3941914)

IC50: 8.60nMAssay Description:Antagonist activity at rat TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50192809(CHEMBL3941914)

IC50: 8.60nMAssay Description:Antagonist activity at recombinant rat TRPV4 expressed in CHOK1 cells assessed as inhibition of 4alphaPDD-induced activation pretreated for 5 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222691(CHEMBL156927)

IC50: 9.30nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

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PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222690(CHEMBL345157)

IC50: 10nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222645(CHEMBL157918)

IC50: 11nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50222693(CHEMBL157579)

IC50: 12nMAssay Description:Antagonistic activity against vanilloid receptor as concentration to reduce the response to 0.5 mM capsaicin by 50% from neonatal rat culture spinal ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232811(CHEMBL4105323)

IC50: 13nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Transient receptor potential cation channel subfamily V member 1/2/4(Rattus norvegicus)
Seoul National University

Curated by ChEMBL

BDBM50224228(CHEMBL46233)

IC50: 15nMAssay Description:In vitro inhibitory concentration was determined against [45Ca2+]- influx in rat DRG neuronsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50192804(CHEMBL3933401)

IC50: 15nMAssay Description:Antagonist activity at rat TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50232794(CHEMBL4082016)

IC50: 16nMAssay Description:Antagonist activity at rat TRPV4 expressed in HEK293 cells assessed as inhibition of GSK634775A-induced calcium influx preincubated for 10 mins follo...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Transient receptor potential cation channel subfamily V member 4(Rattus norvegicus)
Astellas Pharma

Curated by ChEMBL

BDBM50192811(CHEMBL3971502)

IC50: 16nMAssay Description:Antagonist activity at rat TRPV4 assessed as inhibition of 4alpha-PDD-induced activationMore data for this Ligand-Target Pair

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