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Found 66 of ic50 for UniProtKB: P48999
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50043670(2-{(S)-1-[3-Fluoro-5-(naphthalen-2-ylmethoxy)-phen...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of 5-lipoxygenase from mouse macrophageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50043682((R)-2-[3-Fluoro-5-(naphthalen-2-ylmethoxy)-phenyl]...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of 5-lipoxygenase from mouse macrophageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50043669(6-[3-Fluoro-5-((S)-1-methoxy-1-thiazol-2-yl-propyl...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of 5-lipoxygenase from mouse macrophageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50043677((S)-2-[3-Fluoro-5-(naphthalen-2-ylmethoxy)-phenyl]...)
Affinity DataIC50:  5nMAssay Description:Inhibition of 5-lipoxygenase from mouse macrophageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50000832(2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]...)
Affinity DataIC50:  5nMAssay Description:Inhibition of 5-lipoxygenase in mouse macrophages.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50007052(1-[3-(3-Phenyl-allyloxy)-phenyl]-1-thiazol-2-yl-pr...)
Affinity DataIC50:  6nMAssay Description:Inhibition of 5-lipoxygenase in mouse macrophages.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50000857(2-(1-methoxy-1-(3-(naphthalen-2-ylmethoxy)phenyl)p...)
Affinity DataIC50:  8nMAssay Description:Inhibition of 5-lipoxygenase in mouse macrophages.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50043666((R)-2-[3-Fluoro-5-(1-methyl-2-oxo-1,2-dihydro-quin...)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of 5-lipoxygenase from mouse macrophageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50043678((S)-2-[3-Fluoro-5-(1-methyl-2-oxo-1,2-dihydro-quin...)
Affinity DataIC50:  12nMAssay Description:Inhibition of 5-lipoxygenase from mouse macrophageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50007040(2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...)
Affinity DataIC50:  14nMAssay Description:Compound was tested for the inhibition of 5-lipoxygenase (5-LPO) in rat basophilic leukemia (RBL) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50007040(2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...)
Affinity DataIC50:  14nMAssay Description:Inhibition of 5-lipoxygenase in mouse macrophages.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50000832(2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]...)
Affinity DataIC50:  30nMAssay Description:Inhibition of 5-lipoxygenase in mouse macrophages.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50007040(2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...)
Affinity DataIC50: <30nMAssay Description:Inhibition of 5-lipoxygenase in mouse macrophages.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50007057(1-[3-(3-Phenyl-prop-2-ynyloxy)-phenyl]-1-thiazol-2...)
Affinity DataIC50:  30nMAssay Description:Inhibition of 5-lipoxygenase in mouse macrophages.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50000832(2-{1-Methoxy-1-[3-(naphthalen-2-ylmethoxy)-phenyl]...)
Affinity DataIC50:  30nMAssay Description:Inhibition of 5-lipoxygenase in mouse macrophages.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50006811(2-(12-Hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl-p...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity against murine lipoxygenase-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50043676(6-[3-Fluoro-5-((S)-1-methoxy-1-methoxymethyl-propy...)
Affinity DataIC50:  45nMAssay Description:Inhibition of 5-lipoxygenase from mouse macrophageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50043671(6-[3-Fluoro-5-((R)-1-methoxy-1-methoxymethyl-propy...)
Affinity DataIC50:  48nMAssay Description:Inhibition of 5-lipoxygenase from mouse macrophageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50007051(1-[3-(Naphthalen-2-ylmethoxy)-phenyl]-1-thiazol-2-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of 5-lipoxygenase in mouse macrophages.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329397(CHEMBL1269648 | N-(4-Ethylphenyl)-5-methylbenzo[d]...)
Affinity DataIC50:  120nMAssay Description:Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50000541((+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea |...)
Affinity DataIC50:  190nMAssay Description:Inhibition of 5-LO in mouse BMM cells assessed as formation of LTC4 after 30 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50006795(2-(Naphthalen-1-yloxymethyl)-quinoline | CHEMBL847...)
Affinity DataIC50:  200nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase in mouse macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50043672(6-[3-Fluoro-5-((R)-1-methoxy-1-thiazol-2-yl-propyl...)
Affinity DataIC50:  201nMAssay Description:Inhibition of 5-lipoxygenase from mouse macrophageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50007042(2-{Methoxy-[3-(naphthalen-2-ylmethoxy)-phenyl]-met...)
Affinity DataIC50:  300nMAssay Description:Inhibition of 5-lipoxygenase in mouse macrophages.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50145514((E)-1-Furan-2-yl-3-pyridin-2-yl-propenone | CHEMBL...)
Affinity DataIC50:  370nMAssay Description:Inhibitory activity against murine lipoxygenase-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM22372(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Affinity DataIC50:  400nMAssay Description:Inhibition of 5-LOX in calcium ionophore A23187-stimulated NMRI mouse macrophage assessed as inhibition of LTC4 production preincubated for 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50043673(2-{(R)-1-[3-Fluoro-5-(naphthalen-2-ylmethoxy)-phen...)
Affinity DataIC50:  513nMAssay Description:Inhibition of 5-lipoxygenase from mouse macrophageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50007047(1-[3-(3,4-Difluoro-benzyloxy)-phenyl]-1-thiazol-2-...)
Affinity DataIC50:  800nMAssay Description:Inhibition of 5-lipoxygenase in mouse macrophages.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50007060(1-(4-Methyl-thiazol-2-yl)-1-[3-(naphthalen-2-ylmet...)
Affinity DataIC50:  820nMAssay Description:Inhibition of 5-lipoxygenase in mouse macrophages.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329394(5-Chloro-N-(4-ethylphenyl)benzo[d]oxazol-2-amine |...)
Affinity DataIC50:  950nMAssay Description:Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50007048(2-Methyl-1-[3-(naphthalen-2-ylmethoxy)-phenyl]-1-t...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of 5-lipoxygenase in mouse macrophages.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329392(CHEMBL1269619 | N-(4-Ethylphenyl)benzo[d]oxazol-2-...)
Affinity DataIC50:  1.21E+3nMAssay Description:Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50007040(2-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibitory concentration of the compound against 5-lipoxygenase from mouse macrophageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50043675(5-[1-Methoxy-6-(naphthalen-2-ylmethoxy)-indan-1-yl...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of 5-lipoxygenase from mouse macrophageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50128342(CHEMBL3629175)
Affinity DataIC50:  1.72E+3nMAssay Description:Inhibition of 5-LO in mouse BMM cells assessed as formation of LTC4 after 30 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50357364(CHEMBL1242095)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of 5-LOX in calcium ionophore A23187-stimulated NMRI mouse macrophage assessed as inhibition of LTC4 production preincubated for 60 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329404(CHEMBL1269727 | N-(3-Bromophenyl)-5-methoxybenzo[d...)
Affinity DataIC50:  2.03E+3nMAssay Description:Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329402(CHEMBL1269907 | N-(4-Isopropylphenyl)-5-methoxyben...)
Affinity DataIC50:  2.64E+3nMAssay Description:Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329403(5-Methoxy-N-(4-(methylthio)phenyl)benzo[d]oxazol-2...)
Affinity DataIC50:  2.77E+3nMAssay Description:Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50128343(CHEMBL3629176)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of 5-LO in mouse BMM cells assessed as formation of LTC4 after 30 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329393(5-Chloro-N-phenylbenzo[d]oxazol-2-amine | CHEMBL12...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329396(5-Methyl-N-phenylbenzo[d]oxazol-2-amine | CHEMBL12...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50145509((E)-1,3-Di-thiophen-2-yl-propenone | CHEMBL88104)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibitory activity against murine lipoxygenase-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50128344(CHEMBL3629177)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of 5-LO in mouse BMM cells assessed as formation of LTC4 after 30 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329398(CHEMBL1269649 | N-(2-Ethylphenyl)-5-methylbenzo[d]...)
Affinity DataIC50:  5.66E+3nMAssay Description:Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50145518((E)-3-Thiophen-3-yl-1-thiophen-2-yl-propenone | CH...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibitory activity against murine lipoxygenase-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50145515((E)-3-(3-Methyl-thiophen-2-yl)-1-pyridin-2-yl-prop...)
Affinity DataIC50:  6.51E+3nMAssay Description:Inhibitory activity against murine lipoxygenase-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329400(CHEMBL1269704 | N-(3-Methoxyphenyl)-5-methylbenzo[...)
Affinity DataIC50:  6.83E+3nMAssay Description:Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329399(6-Methyl-N-(4-(methylthio)phenyl)benzo[d]oxazol-2-...)
Affinity DataIC50:  7.31E+3nMAssay Description:Inhibition of 5-lipoxygenase in BALB/c mouse BMMC assessed as LTC4 release after 20 mins by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Mus musculus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50145506((E)-1-(5-Chloro-thiophen-2-yl)-3-furan-2-yl-propen...)
Affinity DataIC50:  7.52E+3nMAssay Description:Inhibitory activity against murine lipoxygenase-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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