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Found 137 of ec50 for UniProtKB: P29990
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514196(US11053196, Compound 4B)
Affinity DataEC50:  0.0570nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514148(US11053196, Compound 2B)
Affinity DataEC50:  0.0780nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514203(US11053196, Compound 7A-D)
Affinity DataEC50:  0.100nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514145(US11053196, Compound 1B)
Affinity DataEC50:  0.110nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514197(4-(3-((1-(4-chlorophenyl)-2-(5-fluoro-6-(trifluoro...)
Affinity DataEC50:  0.110nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514194(4-(3-((1-(4-chlorophenyl)-2-(4-methyl-6-(trifluoro...)
Affinity DataEC50:  0.110nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514183(US11053196, Compound 3B)
Affinity DataEC50:  0.120nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514199(US11053196, Compound 5B)
Affinity DataEC50:  0.120nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514205(4-(3-((1-(4-chloro-2-(2-hydroxyethoxy)phenyl)-2-ox...)
Affinity DataEC50:  0.150nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514210(4-(3-((1-(4-chlorophenyl)-2-oxo-2-(6-((trifluorome...)
Affinity DataEC50:  0.280nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514208(US11053196, Compound 10A)
Affinity DataEC50:  0.300nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514146(4-(3-((1-(4-chlorophenyl)-2-(4-methyl-6-(trifluoro...)
Affinity DataEC50:  0.380nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514202(US11053196, Compound 6B)
Affinity DataEC50:  0.390nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514207(4-(3-((1-(4-chlorophenyl)-2-oxo-2-(2-(trifluoromet...)
Affinity DataEC50:  0.520nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514178(4-(3-((1-(4-chlorophenyl)-2-(5-fluoro-6-(trifluoro...)
Affinity DataEC50:  0.560nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514200(4-(3-((1-(4-fluoro-2-methoxyphenyl)-2-oxo-2-(6-(tr...)
Affinity DataEC50:  0.630nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514142(4-(3-((1-(4-chlorophenyl)-2-oxo-2-(6-(pentafluoro-...)
Affinity DataEC50:  0.640nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514206(4-(3-((1-(4-chlorophenyl)-2-(5-methoxy-6-(trifluor...)
Affinity DataEC50:  0.990nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514144(US11053196, Compound 1A)
Affinity DataEC50:  1.30nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514198(US11053196, Compound 5A)
Affinity DataEC50:  2.30nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514195(US11053196, Compound 4A)
Affinity DataEC50:  11nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514147(US11053196, Compound 2A)
Affinity DataEC50:  15nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514204(US11053196, Compound 7B-D)
Affinity DataEC50:  16nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514179(US11053196, Compound 3A)
Affinity DataEC50:  36nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514209(US11053196, Compound 10B)
Affinity DataEC50:  37nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM514201(US11053196, Compound 6A)
Affinity DataEC50:  250nMAssay Description:The antiviral activity of all the compounds of the invention was tested against the DENV-2 16681 strain which was labeled with enhanced green fluores...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567933(CHEMBL4855476)
Affinity DataEC50:  390nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50542799(CHEMBL4649655)
Affinity DataEC50:  490nMAssay Description:Inhibition of Dengue virus serotype 2 NS2B-NS3 protease transfected in human HeLa cells measured after 24 hrs by Renilla-luciferase reporter gene ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50542807(CHEMBL4632524)
Affinity DataEC50:  520nMAssay Description:Inhibition of Dengue virus serotype 2 NS2B-NS3 protease transfected in human HeLa cells measured after 24 hrs by Renilla-luciferase reporter gene ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50592883(CHEMBL5204060)
Affinity DataEC50:  540nMAssay Description:Inhibition of full length DENV2 NS2B-NS3 protease in human HeLa cells expressing luciferase reporter gene incubated for 24 hrs by luminescence analys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567928(CHEMBL4859686)
Affinity DataEC50:  580nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567923(CHEMBL4858512)
Affinity DataEC50:  730nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50542808(CHEMBL4641383)
Affinity DataEC50:  830nMAssay Description:Inhibition of Dengue virus serotype 2 NS2B-NS3 protease transfected in human HeLa cells measured after 24 hrs by Renilla-luciferase reporter gene ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567926(CHEMBL4867213)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567914(CHEMBL4874769)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567929(CHEMBL4851091)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50592879(CHEMBL5201148)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of full length DENV2 NS2B-NS3 protease in human HeLa cells expressing luciferase reporter gene incubated for 24 hrs by luminescence analys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567927(CHEMBL4859856)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567939(CHEMBL4853944)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567934(CHEMBL4857446)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567930(CHEMBL4847125)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567937(CHEMBL4863404)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567938(CHEMBL4875828)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567924(CHEMBL4864503)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567940(CHEMBL4875560)
Affinity DataEC50:  1.70E+3nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567921(CHEMBL4863273)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50542814(CHEMBL4646812)
Affinity DataEC50:  2.10E+3nMAssay Description:Inhibition of Dengue virus serotype 2 NS2B-NS3 protease transfected in human HeLa cells measured after 24 hrs by Renilla-luciferase reporter gene ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50542811(CHEMBL4646053)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of Dengue virus serotype 2 NS2B-NS3 protease transfected in human HeLa cells measured after 24 hrs by Renilla-luciferase reporter gene ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567925(CHEMBL4848292)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Dengue virus 2)
Janssen Pharmaceuticals

US Patent
LigandPNGBDBM50567917(CHEMBL4869395)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of NS2B-NS3 protease in DENV2proHeLa system assessed as inhibition of luciferase signal incubated for 24 hrs by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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