Compile Data Set for Download or QSAR
Found 69 of ic50 for UniProtKB: Q9NQS5
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548398(CHEMBL3718309)
Show SMILES OC(C#Cc1ccc-2c(CCn3c-2cc(OCC2COc4ncccc4O2)nc3=O)c1)c1ccccc1
Show InChI InChI=1S/C29H23N3O5/c33-25(20-5-2-1-3-6-20)11-9-19-8-10-23-21(15-19)12-14-32-24(23)16-27(31-29(32)34)35-17-22-18-36-28-26(37-22)7-4-13-30-28/h1-8,10,13,15-16,22,25,33H,12,14,17-18H2
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50556779(CHEMBL3715656)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(cc3CCn12)C#CCNc1ccccc1
Show InChI InChI=1S/C26H25N3O4/c30-26-28-25(33-18-22-17-31-13-14-32-22)16-24-23-9-8-19(15-20(23)10-12-29(24)26)5-4-11-27-21-6-2-1-3-7-21/h1-3,6-9,15-16,22,27H,10-14,17-18H2
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at human Flag-tagged Gialpha-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in PSB-16671-i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50556779(CHEMBL3715656)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(cc3CCn12)C#CCNc1ccccc1
Show InChI InChI=1S/C26H25N3O4/c30-26-28-25(33-18-22-17-31-13-14-32-22)16-24-23-9-8-19(15-20(23)10-12-29(24)26)5-4-11-27-21-6-2-1-3-7-21/h1-3,6-9,15-16,22,27H,10-14,17-18H2
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS bindin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548387(CHEMBL4794652)
Show SMILES O=c1nc(OCCOc2cnccn2)cc2-c3ccc(CCc4ccccc4)cc3CCn12
Show InChI InChI=1S/C26H24N4O3/c31-26-29-24(32-14-15-33-25-18-27-11-12-28-25)17-23-22-9-8-20(16-21(22)10-13-30(23)26)7-6-19-4-2-1-3-5-19/h1-5,8-9,11-12,16-18H,6-7,10,13-15H2
Affinity DataIC50: 5nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548393(CHEMBL3716446)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(CCc4ccccn4)cc3CCn12
Show InChI InChI=1S/C24H25N3O4/c28-24-26-23(31-16-20-15-29-11-12-30-20)14-22-21-7-5-17(13-18(21)8-10-27(22)24)4-6-19-3-1-2-9-25-19/h1-3,5,7,9,13-14,20H,4,6,8,10-12,15-16H2
Affinity DataIC50: 6nMAssay Description:Antagonist activity at recombinant human GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50556779(CHEMBL3715656)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(cc3CCn12)C#CCNc1ccccc1
Show InChI InChI=1S/C26H25N3O4/c30-26-28-25(33-18-22-17-31-13-14-32-22)16-24-23-9-8-19(15-20(23)10-12-29(24)26)5-4-11-27-21-6-2-1-3-7-21/h1-3,6-9,15-16,22,27H,10-14,17-18H2
Affinity DataIC50: 7.20nMAssay Description:Antagonist activity at human Flag-tagged Gialpha-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in ZQ-16-induc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548393(CHEMBL3716446)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(CCc4ccccn4)cc3CCn12
Show InChI InChI=1S/C24H25N3O4/c28-24-26-23(31-16-20-15-29-11-12-30-20)14-22-21-7-5-17(13-18(21)8-10-27(22)24)4-6-19-3-1-2-9-25-19/h1-3,5,7,9,13-14,20H,4,6,8,10-12,15-16H2
Affinity DataIC50: 8nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548412(CHEMBL4776061)
Show SMILES COc1cc2CCn3c(cc(OCCOc4ccccn4)nc3=O)-c2cc1OC
Show InChI InChI=1S/C21H21N3O5/c1-26-17-11-14-6-8-24-16(15(14)12-18(17)27-2)13-20(23-21(24)25)29-10-9-28-19-5-3-4-7-22-19/h3-5,7,11-13H,6,8-10H2,1-2H3
Affinity DataIC50: 8nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50245516(CHEMBL4090321)
Show SMILES OCCC#Cc1ccc-2c(CCn3c-2cc(OCC2COc4ncccc4O2)cc3=O)c1
Show InChI InChI=1S/C25H22N2O5/c28-11-2-1-4-17-6-7-21-18(12-17)8-10-27-22(21)13-19(14-24(27)29)30-15-20-16-31-25-23(32-20)5-3-9-26-25/h3,5-7,9,12-14,20,28H,2,8,10-11,15-16H2
Affinity DataIC50: 10nMAssay Description:Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50245499(CHEMBL4085616)
Show SMILES O=c1cc(OCC2COc3ncccc3O2)cc2-c3ccc(cc3CCn12)-c1cccnc1
Show InChI InChI=1S/C26H21N3O4/c30-25-13-20(31-15-21-16-32-26-24(33-21)4-2-9-28-26)12-23-22-6-5-17(19-3-1-8-27-14-19)11-18(22)7-10-29(23)25/h1-6,8-9,11-14,21H,7,10,15-16H2
Affinity DataIC50: 10nMAssay Description:Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50245494(CHEMBL4080004)
Show SMILES O=c1cc(OCC2COc3ncccc3O2)cc2-c3ccc(cc3CCn12)-c1cncnc1
Show InChI InChI=1S/C25H20N4O4/c30-24-10-19(31-13-20-14-32-25-23(33-20)2-1-6-28-25)9-22-21-4-3-16(18-11-26-15-27-12-18)8-17(21)5-7-29(22)24/h1-4,6,8-12,15,20H,5,7,13-14H2
Affinity DataIC50: 10nMAssay Description:Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50245491(CHEMBL4098028)
Show SMILES Cc1noc(COc2ccc-3c(CCn4c-3cc(OCC3COc5ncccc5O3)cc4=O)c2)n1
Show InChI InChI=1S/C25H22N4O6/c1-15-27-23(35-28-15)14-32-17-4-5-20-16(9-17)6-8-29-21(20)10-18(11-24(29)30)31-12-19-13-33-25-22(34-19)3-2-7-26-25/h2-5,7,9-11,19H,6,8,12-14H2,1H3
Affinity DataIC50: 10nMAssay Description:Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50245482(CHEMBL4069275)
Show SMILES Cc1cc(COc2ccc-3c(CCn4c-3cc(OCC3COc5ncccc5O3)cc4=O)c2)nn1C
Show InChI InChI=1S/C27H26N4O5/c1-17-10-19(29-30(17)2)14-33-20-5-6-23-18(11-20)7-9-31-24(23)12-21(13-26(31)32)34-15-22-16-35-27-25(36-22)4-3-8-28-27/h3-6,8,10-13,22H,7,9,14-16H2,1-2H3
Affinity DataIC50: 10nMAssay Description:Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50245481(CHEMBL4060589)
Show SMILES O=c1cc(OCC2COc3ncccc3O2)cc2-c3ccc(cc3CCn12)C#Cc1ccncn1
Show InChI InChI=1S/C27H20N4O4/c32-26-14-21(33-15-22-16-34-27-25(35-22)2-1-9-29-27)13-24-23-6-4-18(12-19(23)8-11-31(24)26)3-5-20-7-10-28-17-30-20/h1-2,4,6-7,9-10,12-14,17,22H,8,11,15-16H2
Affinity DataIC50: 10nMAssay Description:Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50245479(CHEMBL4103552)
Show SMILES O=c1cc(OCC2COc3ncccc3O2)cc2-c3ccc(cc3CCn12)-c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C28H22N4O4/c33-27-13-21(34-15-22-16-35-28-26(36-22)2-1-8-29-28)12-25-23-5-3-17(10-19(23)7-9-32(25)27)18-4-6-24-20(11-18)14-30-31-24/h1-6,8,10-14,22H,7,9,15-16H2,(H,30,31)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50245480(CHEMBL4082477)
Show SMILES NC(=O)c1cccc(c1)-c1ccc-2c(CCn3c-2cc(OCC2COc4ncccc4O2)cc3=O)c1
Show InChI InChI=1S/C28H23N3O5/c29-27(33)20-4-1-3-17(12-20)18-6-7-23-19(11-18)8-10-31-24(23)13-21(14-26(31)32)34-15-22-16-35-28-25(36-22)5-2-9-30-28/h1-7,9,11-14,22H,8,10,15-16H2,(H2,29,33)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at GPR84 (unknown origin) expressed in cell membranes after 90 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548412(CHEMBL4776061)
Show SMILES COc1cc2CCn3c(cc(OCCOc4ccccn4)nc3=O)-c2cc1OC
Show InChI InChI=1S/C21H21N3O5/c1-26-17-11-14-6-8-24-16(15(14)12-18(17)27-2)13-20(23-21(24)25)29-10-9-28-19-5-3-4-7-22-19/h3-5,7,11-13H,6,8-10H2,1-2H3
Affinity DataIC50: 11nMAssay Description:Antagonist activity at recombinant human GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50556778(CHEMBL3717743)
Show SMILES O=c1nc(OC[C@H]2COCCO2)cc2-c3ccc(OCc4noc(n4)C4CC4)cc3CCn12
Show InChI InChI=1S/C23H24N4O6/c28-23-25-21(32-12-17-11-29-7-8-30-17)10-19-18-4-3-16(9-15(18)5-6-27(19)23)31-13-20-24-22(33-26-20)14-1-2-14/h3-4,9-10,14,17H,1-2,5-8,11-13H2/t17-/m1/s1
Affinity DataIC50: 14nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50556779(CHEMBL3715656)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(cc3CCn12)C#CCNc1ccccc1
Show InChI InChI=1S/C26H25N3O4/c30-26-28-25(33-18-22-17-31-13-14-32-22)16-24-23-9-8-19(15-20(23)10-12-29(24)26)5-4-11-27-21-6-2-1-3-7-21/h1-3,6-9,15-16,22,27H,10-14,17-18H2
Affinity DataIC50: 14nMAssay Description:Antagonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50556779(CHEMBL3715656)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(cc3CCn12)C#CCNc1ccccc1
Show InChI InChI=1S/C26H25N3O4/c30-26-28-25(33-18-22-17-31-13-14-32-22)16-24-23-9-8-19(15-20(23)10-12-29(24)26)5-4-11-27-21-6-2-1-3-7-21/h1-3,6-9,15-16,22,27H,10-14,17-18H2
Affinity DataIC50: 21nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548420(CHEMBL4750532)
Show SMILES CCCCCCOc1cc2-c3cc(OC)c(OC)cc3CCn2c(=O)n1
Show InChI InChI=1S/C20H26N2O4/c1-4-5-6-7-10-26-19-13-16-15-12-18(25-3)17(24-2)11-14(15)8-9-22(16)20(23)21-19/h11-13H,4-10H2,1-3H3
Affinity DataIC50: 21nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548391(CHEMBL3717201)
Show SMILES CN(CC#Cc1ccc-2c(CCn3c-2cc(OCC2COCCO2)nc3=O)c1)Cc1ccccc1
Show InChI InChI=1S/C28H29N3O4/c1-30(18-22-6-3-2-4-7-22)12-5-8-21-9-10-25-23(16-21)11-13-31-26(25)17-27(29-28(31)32)35-20-24-19-33-14-15-34-24/h2-4,6-7,9-10,16-17,24H,11-15,18-20H2,1H3
Affinity DataIC50: 22nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548401(CHEMBL4755764)
Show SMILES COc1ccc-2c(CCn3c-2cc(OCC2COc4ncccc4O2)nc3=O)c1
Show InChI InChI=1S/C21H19N3O5/c1-26-14-4-5-16-13(9-14)6-8-24-17(16)10-19(23-21(24)25)27-11-15-12-28-20-18(29-15)3-2-7-22-20/h2-5,7,9-10,15H,6,8,11-12H2,1H3
Affinity DataIC50: 22nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50556779(CHEMBL3715656)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(cc3CCn12)C#CCNc1ccccc1
Show InChI InChI=1S/C26H25N3O4/c30-26-28-25(33-18-22-17-31-13-14-32-22)16-24-23-9-8-19(15-20(23)10-12-29(24)26)5-4-11-27-21-6-2-1-3-7-21/h1-3,6-9,15-16,22,27H,10-14,17-18H2
Affinity DataIC50: 22nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548392(CHEMBL3717853)
Show SMILES CC(C)CC(O)C#Cc1ccc-2c(CCn3c-2cc(OCC2COCCO2)nc3=O)c1
Show InChI InChI=1S/C24H28N2O5/c1-16(2)11-19(27)5-3-17-4-6-21-18(12-17)7-8-26-22(21)13-23(25-24(26)28)31-15-20-14-29-9-10-30-20/h4,6,12-13,16,19-20,27H,7-11,14-15H2,1-2H3
Affinity DataIC50: 25nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50556779(CHEMBL3715656)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(cc3CCn12)C#CCNc1ccccc1
Show InChI InChI=1S/C26H25N3O4/c30-26-28-25(33-18-22-17-31-13-14-32-22)16-24-23-9-8-19(15-20(23)10-12-29(24)26)5-4-11-27-21-6-2-1-3-7-21/h1-3,6-9,15-16,22,27H,10-14,17-18H2
Affinity DataIC50: 25nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548394(CHEMBL3717416)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(COC4CCCC4)cc3CCn12
Show InChI InChI=1S/C23H28N2O5/c26-23-24-22(30-15-19-14-27-9-10-28-19)12-21-20-6-5-16(11-17(20)7-8-25(21)23)13-29-18-3-1-2-4-18/h5-6,11-12,18-19H,1-4,7-10,13-15H2
Affinity DataIC50: 26nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50556778(CHEMBL3717743)
Show SMILES O=c1nc(OC[C@H]2COCCO2)cc2-c3ccc(OCc4noc(n4)C4CC4)cc3CCn12
Show InChI InChI=1S/C23H24N4O6/c28-23-25-21(32-12-17-11-29-7-8-30-17)10-19-18-4-3-16(9-15(18)5-6-27(19)23)31-13-20-24-22(33-26-20)14-1-2-14/h3-4,9-10,14,17H,1-2,5-8,11-13H2/t17-/m1/s1
Affinity DataIC50: 28nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548403(CHEMBL3714917)
Show SMILES COc1ccc-2c(CCn3c-2cc(OCC2COc4ccccc4O2)nc3=O)c1
Show InChI InChI=1S/C22H20N2O5/c1-26-15-6-7-17-14(10-15)8-9-24-18(17)11-21(23-22(24)25)28-13-16-12-27-19-4-2-3-5-20(19)29-16/h2-7,10-11,16H,8-9,12-13H2,1H3
Affinity DataIC50: 50nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548385(Glpg-1205 | Glpg1205)
Show SMILES O=c1nc(OC[C@@H]2COCCO2)cc2-c3ccc(cc3CCn12)C#CC1CC1
Show InChI InChI=1S/C22H22N2O4/c25-22-23-21(28-14-18-13-26-9-10-27-18)12-20-19-6-5-16(4-3-15-1-2-15)11-17(19)7-8-24(20)22/h5-6,11-12,15,18H,1-2,7-10,13-14H2/t18-/m0/s1
Affinity DataIC50: 54nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50556780(CHEMBL3715918)
Show SMILES O=c1nc(OC[C@@H]2COCCO2)cc2-c3ccc(COCC4CCOCC4)cc3CCn12
Show InChI InChI=1S/C24H30N2O6/c27-24-25-23(32-16-20-15-29-9-10-31-20)12-22-21-2-1-18(11-19(21)3-6-26(22)24)14-30-13-17-4-7-28-8-5-17/h1-2,11-12,17,20H,3-10,13-16H2/t20-/m0/s1
Affinity DataIC50: 55nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548390(CHEMBL3719092)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(cc3CCn12)C#CC1CC1
Show InChI InChI=1S/C22H22N2O4/c25-22-23-21(28-14-18-13-26-9-10-27-18)12-20-19-6-5-16(4-3-15-1-2-15)11-17(19)7-8-24(20)22/h5-6,11-12,15,18H,1-2,7-10,13-14H2
Affinity DataIC50: 55nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548416(CHEMBL4756307)
Show SMILES COc1cc2CCn3c(cc(OCCOc4ccccc4)nc3=O)-c2cc1OC
Show InChI InChI=1S/C22H22N2O5/c1-26-19-12-15-8-9-24-18(17(15)13-20(19)27-2)14-21(23-22(24)25)29-11-10-28-16-6-4-3-5-7-16/h3-7,12-14H,8-11H2,1-2H3
Affinity DataIC50: 63nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50556780(CHEMBL3715918)
Show SMILES O=c1nc(OC[C@@H]2COCCO2)cc2-c3ccc(COCC4CCOCC4)cc3CCn12
Show InChI InChI=1S/C24H30N2O6/c27-24-25-23(32-16-20-15-29-9-10-31-20)12-22-21-2-1-18(11-19(21)3-6-26(22)24)14-30-13-17-4-7-28-8-5-17/h1-2,11-12,17,20H,3-10,13-16H2/t20-/m0/s1
Affinity DataIC50: 83nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548395(CHEMBL3718005)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(NCc4ccco4)cc3CCn12
Show InChI InChI=1S/C22H23N3O5/c26-22-24-21(30-14-18-13-27-8-9-29-18)11-20-19-4-3-16(10-15(19)5-6-25(20)22)23-12-17-2-1-7-28-17/h1-4,7,10-11,18,23H,5-6,8-9,12-14H2
Affinity DataIC50: 84nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50556778(CHEMBL3717743)
Show SMILES O=c1nc(OC[C@H]2COCCO2)cc2-c3ccc(OCc4noc(n4)C4CC4)cc3CCn12
Show InChI InChI=1S/C23H24N4O6/c28-23-25-21(32-12-17-11-29-7-8-30-17)10-19-18-4-3-16(9-15(18)5-6-27(19)23)31-13-20-24-22(33-26-20)14-1-2-14/h3-4,9-10,14,17H,1-2,5-8,11-13H2/t17-/m1/s1
Affinity DataIC50: 86nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548386(CHEMBL3717363)
Show SMILES O=c1nc(OC[C@H]2COCCO2)cc2-c3ccc(cc3CCn12)C#CC1CC1
Show InChI InChI=1S/C22H22N2O4/c25-22-23-21(28-14-18-13-26-9-10-27-18)12-20-19-6-5-16(4-3-15-1-2-15)11-17(19)7-8-24(20)22/h5-6,11-12,15,18H,1-2,7-10,13-14H2/t18-/m1/s1
Affinity DataIC50: 102nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548396(CHEMBL4744625)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(cc3CCn12)C1CC1
Show InChI InChI=1S/C20H22N2O4/c23-20-21-19(26-12-16-11-24-7-8-25-16)10-18-17-4-3-14(13-1-2-13)9-15(17)5-6-22(18)20/h3-4,9-10,13,16H,1-2,5-8,11-12H2
Affinity DataIC50: 107nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548406(CHEMBL4757870)
Show SMILES COc1ccc-2c(CCn3c-2cc(OCCOc2ccccc2)nc3=O)c1
Show InChI InChI=1S/C21H20N2O4/c1-25-17-7-8-18-15(13-17)9-10-23-19(18)14-20(22-21(23)24)27-12-11-26-16-5-3-2-4-6-16/h2-8,13-14H,9-12H2,1H3
Affinity DataIC50: 156nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548421(CHEMBL4795786)
Show SMILES COc1cc2CCn3c(cc(OCc4ccccc4)nc3=O)-c2cc1OC
Show InChI InChI=1S/C21H20N2O4/c1-25-18-10-15-8-9-23-17(16(15)11-19(18)26-2)12-20(22-21(23)24)27-13-14-6-4-3-5-7-14/h3-7,10-12H,8-9,13H2,1-2H3
Affinity DataIC50: 157nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50556780(CHEMBL3715918)
Show SMILES O=c1nc(OC[C@@H]2COCCO2)cc2-c3ccc(COCC4CCOCC4)cc3CCn12
Show InChI InChI=1S/C24H30N2O6/c27-24-25-23(32-16-20-15-29-9-10-31-20)12-22-21-2-1-18(11-19(21)3-6-26(22)24)14-30-13-17-4-7-28-8-5-17/h1-2,11-12,17,20H,3-10,13-16H2/t20-/m0/s1
Affinity DataIC50: 168nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548399(CHEMBL3718710)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(cc3CCn12)-c1ccccc1C#N
Show InChI InChI=1S/C24H21N3O4/c25-13-18-3-1-2-4-20(18)16-5-6-21-17(11-16)7-8-27-22(21)12-23(26-24(27)28)31-15-19-14-29-9-10-30-19/h1-6,11-12,19H,7-10,14-15H2
Affinity DataIC50: 212nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548417(CHEMBL4799579)
Show SMILES COc1cc2CCn3c(cc(OCc4ccccc4F)nc3=O)-c2cc1OC
Show InChI InChI=1S/C21H19FN2O4/c1-26-18-9-13-7-8-24-17(15(13)10-19(18)27-2)11-20(23-21(24)25)28-12-14-5-3-4-6-16(14)22/h3-6,9-11H,7-8,12H2,1-2H3
Affinity DataIC50: 252nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50556781(CHEMBL3719364)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccc(OCc4ccccn4)cc3CCn12
Show InChI InChI=1S/C23H23N3O5/c27-23-25-22(31-15-19-14-28-9-10-29-19)12-21-20-5-4-18(11-16(20)6-8-26(21)23)30-13-17-3-1-2-7-24-17/h1-5,7,11-12,19H,6,8-10,13-15H2
Affinity DataIC50: 260nMAssay Description:Antagonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in 6-OAU-induced inhibition of forskolin stimulated cAMP productio...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548400(CHEMBL3717307)
Show SMILES OC(=O)COc1ccc-2c(CCn3c-2cc(OCC2COc4ccccc4O2)nc3=O)c1
Show InChI InChI=1S/C23H20N2O7/c26-22(27)13-29-15-5-6-17-14(9-15)7-8-25-18(17)10-21(24-23(25)28)31-12-16-11-30-19-3-1-2-4-20(19)32-16/h1-6,9-10,16H,7-8,11-13H2,(H,26,27)
Affinity DataIC50: 274nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548415(CHEMBL4760776)
Show SMILES COc1cc2CCn3c(cc(OCc4ncccc4F)nc3=O)-c2cc1OC
Show InChI InChI=1S/C20H18FN3O4/c1-26-17-8-12-5-7-24-16(13(12)9-18(17)27-2)10-19(23-20(24)25)28-11-15-14(21)4-3-6-22-15/h3-4,6,8-10H,5,7,11H2,1-2H3
Affinity DataIC50: 350nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548414(CHEMBL4758226)
Show SMILES COc1cc2CCn3c(cc(OCC4CCCO4)nc3=O)-c2cc1OC
Show InChI InChI=1S/C19H22N2O5/c1-23-16-8-12-5-6-21-15(14(12)9-17(16)24-2)10-18(20-19(21)22)26-11-13-4-3-7-25-13/h8-10,13H,3-7,11H2,1-2H3
Affinity DataIC50: 383nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548404(CHEMBL3718436)
Show SMILES COc1ccc-2c(CCn3c-2cc(OCC2COCCO2)nc3=O)c1
Show InChI InChI=1S/C18H20N2O5/c1-22-13-2-3-15-12(8-13)4-5-20-16(15)9-17(19-18(20)21)25-11-14-10-23-6-7-24-14/h2-3,8-9,14H,4-7,10-11H2,1H3
Affinity DataIC50: 431nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548397(CHEMBL3715879)
Show SMILES O=c1nc(OCC2COCCO2)cc2-c3ccccc3CCn12
Show InChI InChI=1S/C17H18N2O4/c20-17-18-16(23-11-13-10-21-7-8-22-13)9-15-14-4-2-1-3-12(14)5-6-19(15)17/h1-4,9,13H,5-8,10-11H2
Affinity DataIC50: 466nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos SASU

Curated by ChEMBL
LigandPNGBDBM50548408(CHEMBL4757413)
Show SMILES COc1ccc-2c(CCn3c-2cc(OCc2ncccc2F)nc3=O)c1
Show InChI InChI=1S/C19H16FN3O3/c1-25-13-4-5-14-12(9-13)6-8-23-17(14)10-18(22-19(23)24)26-11-16-15(20)3-2-7-21-16/h2-5,7,9-10H,6,8,11H2,1H3
Affinity DataIC50: 595nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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