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Found 55 Enz. Inhib. hit(s) with all data for entry = 50016351
TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518186(US11111247, Example 17)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50:  0.980nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518194(US11111247, Example 24)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518193(US11111247, Example 23)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518135(US11111247, Example 1)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518180(US11111247, Example 11)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518186(US11111247, Example 17)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518172(US11111247, Example 8)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518170(US11111247, Example 6)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHepcidin(Homo sapiens)
Incyte

Curated by ChEMBL
LigandPNGBDBM518186(US11111247, Example 17)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of Hepcidin in human Huh-7 cells assessed as inhibition of BMP-7 induced hepcidin production incubated for 16 to 24 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518169(US11111247, Example 5)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50594431(CHEMBL5178082)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518194(US11111247, Example 24)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518193(US11111247, Example 23)
Affinity DataIC50:  22nMAssay Description:Inhibition of recombinant human C-terminal GST tagged ALK1 (144 to end residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518156(US11111247, Example 2)
Affinity DataIC50:  23nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518186(US11111247, Example 17)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant human GST-tagged full length ALK5 expressed in baculovirus assessed as loss of peptide phosphorylation activity using pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518186(US11111247, Example 17)
Affinity DataIC50:  27nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHepcidin(Homo sapiens)
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  28nMAssay Description:Inhibition of Hepcidin in human Huh-7 cells assessed as inhibition of BMP-7 induced hepcidin production incubated for 16 to 24 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHepcidin(Homo sapiens)
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50:  34nMAssay Description:Inhibition of Hepcidin in human Huh-7 cells assessed as inhibition of BMP-7 induced hepcidin production incubated for 16 to 24 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  39nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50594432(CHEMBL5181658)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518194(US11111247, Example 24)
Affinity DataIC50:  48nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  52nMAssay Description:Inhibition of recombinant human GST-tagged full length ALK5 expressed in baculovirus assessed as loss of peptide phosphorylation activity using pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHepcidin(Homo sapiens)
Incyte

Curated by ChEMBL
LigandPNGBDBM518194(US11111247, Example 24)
Affinity DataIC50:  58nMAssay Description:Inhibition of Hepcidin in human Huh-7 cells assessed as inhibition of BMP-7 induced hepcidin production incubated for 16 to 24 hrs by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50:  61nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50594430(CHEMBL5199942)
Affinity DataIC50:  77nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50594429(CHEMBL5187962)
Affinity DataIC50:  95nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518194(US11111247, Example 24)
Affinity DataIC50:  98nMAssay Description:Inhibition of recombinant human GST-tagged full length ALK5 expressed in baculovirus assessed as loss of peptide phosphorylation activity using pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human GST-tagged full length ALK5 expressed in baculovirus assessed as loss of peptide phosphorylation activity using pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518193(US11111247, Example 23)
Affinity DataIC50:  119nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50:  176nMAssay Description:Inhibition of FGFR3 (unknown origin) using peptide substrate incubated for 90 mins in presence of ATP by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518193(US11111247, Example 23)
Affinity DataIC50:  207nMAssay Description:Inhibition of recombinant human GST-tagged full length ALK5 expressed in baculovirus assessed as loss of peptide phosphorylation activity using pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518180(US11111247, Example 11)
Affinity DataIC50:  212nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518156(US11111247, Example 2)
Affinity DataIC50:  245nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518186(US11111247, Example 17)
Affinity DataIC50:  251nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518170(US11111247, Example 6)
Affinity DataIC50:  346nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518172(US11111247, Example 8)
Affinity DataIC50:  350nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518194(US11111247, Example 24)
Affinity DataIC50:  383nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518135(US11111247, Example 1)
Affinity DataIC50:  384nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518173(US11111247, Example 9)
Affinity DataIC50:  538nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518169(US11111247, Example 5)
Affinity DataIC50:  661nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50594433(CHEMBL5189003)
Affinity DataIC50:  793nMAssay Description:Inhibition of human recombinant N-terminal GST tagged ALK2 (147 to end residues) expressed in baculovirus infected in Sf9 cells assessed as loss of p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50:  901nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518193(US11111247, Example 23)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ALK3 (187 to 532 residues) expressed in baculovirus assessed as loss of peptide phosphorylation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetActivin receptor type-1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50594429(CHEMBL5187962)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibition of ALK2 in human HeLa cells assessed as reduction in BMP-7 induced SMAD1 phosphorylation incubated for 1 hr followed BMP-7 stimulation for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCytochrome P450 2C19(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCytochrome P450 2D6(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM518192(US11111247, Example 22)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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