Compile Data Set for Download or QSAR
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Found 4332 Enz. Inhib. hit(s) with Target = 'Bile acid receptor'
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM21725((1S,2R,10R,11S,14Z,15S)-14-ethylidene-2,15-dimethy...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibitory concentration against Farnesoid X receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50226465(CHEMBL402063 | E-guggulsterone | pregna-4,17(20)-c...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibitory concentration against Farnesoid X receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50510487(CHEMBL4569266)
Affinity DataIC50: <0.00100nMAssay Description:Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50510491(CHEMBL4552760)
Affinity DataIC50: <0.00100nMAssay Description:Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50286760(CHEMBL4170032)
Affinity DataIC50: <0.00100nMAssay Description:Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50510491(CHEMBL4552760)
Affinity DataIC50: <0.00100nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50286760(CHEMBL4170032)
Affinity DataIC50: <0.00100nMAssay Description:Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50552997(CHEMBL4797745)
Affinity DataIC50: <0.00100nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50286734(CHEMBL4172988)
Affinity DataIC50: <0.00100nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50286761(CHEMBL4169187)
Affinity DataIC50:  0.00200nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50286736(CHEMBL4161262)
Affinity DataIC50:  0.00600nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50286763(CHEMBL4169596)
Affinity DataIC50:  0.0500nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50553000(CHEMBL4783205)
Affinity DataIC50:  0.0500nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50510495(CHEMBL4453417)
Affinity DataIC50:  0.0500nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50510495(CHEMBL4453417)
Affinity DataIC50:  0.0500nMAssay Description:Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50286733(CHEMBL4162312)
Affinity DataIC50:  0.0600nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50552999(CHEMBL4749439)
Affinity DataIC50:  0.0600nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50552998(CHEMBL4783777)
Affinity DataIC50:  0.0900nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM77055(US10093697, 8. | US10487111, Example 8. | US969401...)
Affinity DataIC50:  0.110nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric┐SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50552996(CHEMBL4785930)
Affinity DataIC50:  0.110nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM77086(US10093697, 13. | US10487111, Example 13. | US9694...)
Affinity DataIC50:  0.130nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric┐SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM77080(US10093697, 11. | US9694018, 11)
Affinity DataIC50:  0.150nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric┐SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM77040(US10093697, 5. | US10487111, Example 5. | US969401...)
Affinity DataIC50:  0.160nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric┐SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM77029(US10093697, 3. | US10487111, Example 3. | US969401...)
Affinity DataIC50:  0.180nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric┐SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM77074(US10093697, 10. | US10487111, Example 10. | US9694...)
Affinity DataIC50:  0.200nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric┐SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50286762(CHEMBL4159402)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM225964(FXR_55)
Affinity DataIC50:  0.300nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM77083(US10093697, 12. | US10487111, Example 12. | US9694...)
Affinity DataIC50:  0.300nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric┐SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM77033(US10093697, 4. | US10487111, Example 4. | US969401...)
Affinity DataIC50:  0.350nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric┐SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM77051(US10093697, 7. | US10487111, Example 7. | US969401...)
Affinity DataIC50:  0.360nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric┐SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM76996(US10487111, Example 2. | US9694018, 2)
Affinity DataIC50:  0.390nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric┐SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM76994(US10093697, 1. | US10487111, Example 1. | US969401...)
Affinity DataIC50:  0.450nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric┐SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50286764(CHEMBL4176369)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human FXR expressed in Hep3B cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50236558(CHEMBL4101903)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human FXR expressed in COS1 cells assessed as inhibition of CDCA-induced receptor activation after 2 days by luciferase report...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50336375((S)-1-(4-(2-(2-(4-chlorophenyl)-5,6-difluoro-1H-be...)
Affinity DataIC50:  1nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM77088(US10093697, 14. | US10487111, Example 14. | US9694...)
Affinity DataIC50:  1.20nMAssay Description:ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric┐SPA Inhibitor IC50 Mean IC50 (nM) was...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50463011(CHEMBL4241985)
Affinity DataIC50:  1.30nMAssay Description:Antagonist activity at full length human FXR expressed in HeLa cells co-expressing BSEP-pGL3/pSG5-hRXR after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50553001(CHEMBL4778665)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity against recombinant human FXR transfected in human HuH-7 cells co-transfected with FRE-luciferase assessed as reduction in CDCA-i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50510488(CHEMBL4519419)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity at human FXR expressed in Huh7 cells assessed as inhibition of CDCA-induced FXR response element driven luciferase activity after...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50336376((S)-4-(2-(2-(4-chlorophenyl)-5,6-difluoro-1H-benzo...)
Affinity DataIC50:  4nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50510491(CHEMBL4552760)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at recombinant GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced Fluorecein-SRC2-2 coactivator peptide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50510491(CHEMBL4552760)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced fluorecein-labeled SRC2-2 coactivator recruitment...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50015421(CHEMBL3264644)
Affinity DataIC50:  7.5nMAssay Description:Antagonist activity at human GST-tagged FXR after 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50552997(CHEMBL4797745)
Affinity DataIC50:  7.80nMAssay Description:Antagonist activity at recombinant GST-tagged FXR LBD (unknown origin) assessed as inhibition of GW4064-induced Fluorecein-SRC2-2 coactivator peptide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM225944(FXR_34)
Affinity DataIC50:  7.90nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50336377((S)-4-(2-(2-(4-chlorophenyl)-5,6-difluoro-1H-benzo...)
Affinity DataIC50:  8nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50336378((S)-2-(2-(4-chlorophenyl)-5,6-difluoro-1H-benzo[d]...)
Affinity DataIC50:  8nMAssay Description:Displacement of radioligand from human FXR by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM225941(FXR_31)
Affinity DataIC50:  8.40nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM50336379((S)-3-chloro-4-(2-(2-(4-chlorophenyl)-5,6-difluoro...)
Affinity DataIC50:  8.70nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Universit£ di Perugia

Curated by ChEMBL
LigandPNGBDBM225933(FXR_22)
Affinity DataIC50:  8.90nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
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