Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50037712
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188449([D-4Aph(CO-NH-OCH3)6]degarelix | CHEMBL435141)
Affinity DataIC50: 0.510nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50102450(degarelix | Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(D...)
Affinity DataIC50: 0.580nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188439([4Aph(CO-NH-OCH3)5]degarelix | CHEMBL407661)
Affinity DataIC50: 0.600nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50102456(acyline | Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(Ac)...)
Affinity DataIC50: 0.690nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188454([N-alpha-Me-4Aph(CO-NH-OCH3)5,D-4Aph(CO-NH-OCH3)6]...)
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188430([D-4Aph(CO-NH-OH)6]degarelix | CHEMBL427976)
Affinity DataIC50: 0.800nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188451([4Aph(CO-NH-OH)5]degarelix | CHEMBL429527)
Affinity DataIC50: 0.860nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188426([D-4Aph(CO-NH-(C2H4O)2-C2H5)6]degarelix | CHEMBL43...)
Affinity DataIC50: 0.880nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188432([4Aph(CO-NH-OCH3)5,D-4Aph(CO-NH-OCH3)6]degarelix |...)
Affinity DataIC50: 0.910nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188453([4Aph(CO-(C2H4O)3-C2H4-NH-CO-NH-OCH3)5]degarelix |...)
Affinity DataIC50: 1.06nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188431(des-Ac-[4Aph(CO-NH-(C2H4O)2-C2H5)5]-C2H5-(C2H4O)2-...)
Affinity DataIC50: 1.12nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188435(des-Ac-[4Aph(CO-NH-OCH3)5,D-4Aph(CO-NH-OCH3)6]-CH3...)
Affinity DataIC50: 1.37nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188427(des-Ac-[4Aph(CO-NH-OCH3)5]-CH3-(CH2)2-CO-degarelix...)
Affinity DataIC50: 1.46nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188429([D-Dab(CO-NH-OCH3)3, 4Aph(CO-NH-OCH3)5,D-4Aph(CO-N...)
Affinity DataIC50: 1.49nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188444([4Aph(CO-NH-OCH3)5,D-4Aph(CO-NH-OCH3)6,Orn(IGly)8]...)
Affinity DataIC50: 1.53nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188436(des-Ac-[D-4Aph(CO-NH-OCH3)6]-C2H5-(C2H4O)2-NH-COde...)
Affinity DataIC50: 1.61nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188433([4Aph(CO-NH-OCH3)5,D-4Aph(CO-(C2H4O)6-C2H4-NH-CONH...)
Affinity DataIC50: 1.67nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188428([D-Dab(CO-NH-OCH3)3]degarelix | CHEMBL411337)
Affinity DataIC50: 1.69nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188446([4Aph(CO-NH-(C2H4O)2-C2H5)5,D-4Aph(CO-NH-(C2H4O)2-...)
Affinity DataIC50: 2.04nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188438(des-Ac-[D-4Aph(CO-NH-OCH3)6]-CH3-(CH2)2-CO-degarel...)
Affinity DataIC50: 2.13nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188440(des-Ac-[4Aph(CO-NH-(C2H4O)2-C2H5)5,D-4Aph(CO-NH-(C...)
Affinity DataIC50: 2.55nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188445([D-Dab(CO-NH-OH)3]degarelix | CHEMBL425813)
Affinity DataIC50: 2.68nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188452([D-Gln3, 4Aph(CO-NH-OCH3)5,D-4Aph(CO-NH-OCH3)6]-de...)
Affinity DataIC50: 2.98nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188450(des-Ac-[4Aph(CO-NH-OCH3)5]-C2H5-(C2H4O)2-NH-CO-deg...)
Affinity DataIC50: 2.98nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188441([D-Dap(CO-NH-OCH3)3]degarelix | CHEMBL411381)
Affinity DataIC50: 3.16nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188434([4Aph(CO-NH-(C2H4O)2-C2H5)5]degarelix | CHEMBL2195...)
Affinity DataIC50: 3.16nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188442([D-Dap(CO-NH-OH)3]degarelix | CHEMBL428484)
Affinity DataIC50: 3.46nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188447(des-Ac-[4Aph(CO-NH-OCH3)5]-CH3-(CH2)6-CO-degarelix...)
Affinity DataIC50: 4.17nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188443(des-Ac-[D-4Aph(CO-NH-(C2H4O)2-C2H5)6]-C2H5-(C2H4O)...)
Affinity DataIC50: 4.55nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188437(des-Ac-[4Aph(CO-NH-OCH3)5,D-4Aph(CO-NH-OCH3)6]-CH3...)
Affinity DataIC50: 4.99nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Salk Institute

Curated by ChEMBL
LigandPNGBDBM50188448(des-Ac-[D-4Aph(CO-NH-OCH3)6]-CH3-(CH2)6-CO-degarel...)
Affinity DataIC50: 9.47nMAssay Description:Antagonist activity at human GnRH receptor expressed in HEK293 cells as inhibition of GnRH-induced LH secretion by reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2012
Entry Details Article
PubMed