Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 1776
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14050(N-(1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(trifluoro...)
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14051(4-(3,4-Dichlorophenyl)-N-1H-indazol-5-yl-2-methyl-...)
Affinity DataIC50: 8nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14056(N-(7-chloro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(...)
Affinity DataIC50: 8nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14052(N-(1H-indazol-5-yl)-2-methyl-4-(naphthalen-2-yl)-6...)
Affinity DataIC50: 9nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14053(2-methyl-N-(3-methyl-1H-indazol-5-yl)-6-oxo-4-[4-(...)
Affinity DataIC50: 9nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14055(N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(...)
Affinity DataIC50: 14nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14048(JMC516631 Compound 1 | 4-(4-fluorophenyl)-N-(1H-in...)
Affinity DataIC50: 14nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14049(4-(4-Fluorophenyl)-N-1H-indazol-5-yl-2-methyl-6-ox...)
Affinity DataIC50: 51nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14054(N-(4-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-4-[4-(...)
Affinity DataIC50: 2.50E+3nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2007
Entry Details Article
PubMed