Compile Data Set for Download or QSAR
Report error Found 197 Enz. Inhib. hit(s) with all data for entry = 50038562
TargetPlatelet-derived growth factor receptor beta(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.200nMAssay Description:Inhibition of PDGFRbeta by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.200nMAssay Description:Inhibition of KDR by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of EGFR by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAurora kinase A-interacting protein(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.700nMAssay Description:Inhibition of KitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  0.800nMAssay Description:Inhibition of FLT3 by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fes/Fps(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(Type II inhibitor, 14 | CHEMBL459850 | N-(3-(7-Ami...)
Affinity DataIC50: 1nMAssay Description:Inhibition of FesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(Type II inhibitor, 14 | CHEMBL459850 | N-(3-(7-Ami...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of BmxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50161957(CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...)
Affinity DataEC50:  2nMAssay Description:Inhibition of human Her2 in SKBR3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50161957(CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...)
Affinity DataEC50:  2nMAssay Description:Inhibition of human Her2 in BT474 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetEphrin type-A receptor 3(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(Type II inhibitor, 14 | CHEMBL459850 | N-(3-(7-Ami...)
Affinity DataEC50:  2nMAssay Description:Inhibition of EphA3 by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataEC50:  3nMAssay Description:Inhibition of ALK by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataEC50:  3nMAssay Description:Inhibition of B-raf by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 3nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM12255(CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEphrin type-B receptor 4(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(Type II inhibitor, 14 | CHEMBL459850 | N-(3-(7-Ami...)
Affinity DataEC50:  4nMAssay Description:Inhibition of EphB4 by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(Type II inhibitor, 14 | CHEMBL459850 | N-(3-(7-Ami...)
Affinity DataEC50:  4nMAssay Description:Inhibition of PDGFRalpha by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(Type II inhibitor, 14 | CHEMBL459850 | N-(3-(7-Ami...)
Affinity DataEC50:  4nMAssay Description:Inhibition of c-Kit by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Yes(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM12255(CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of c-YesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM12255(CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of Lck by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetAurora kinase C(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of Aurora CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(Type II inhibitor, 14 | CHEMBL459850 | N-(3-(7-Ami...)
Affinity DataEC50:  5nMAssay Description:Inhibition of Lck by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(Type II inhibitor, 14 | CHEMBL459850 | N-(3-(7-Ami...)
Affinity DataEC50:  6nMAssay Description:Inhibition of PDGFRbeta by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 8nMAssay Description:Inhibition of c-Met by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  9nMAssay Description:Inhibition of Jak1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242737((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)
Affinity DataIC50: 9nMAssay Description:Inhibition of c-Met by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 12nMAssay Description:Inhibition of Tie2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(Type II inhibitor, 14 | CHEMBL459850 | N-(3-(7-Ami...)
Affinity DataEC50:  13nMAssay Description:Inhibition of Src by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(Type II inhibitor, 14 | CHEMBL459850 | N-(3-(7-Ami...)
Affinity DataIC50: 13nMAssay Description:Inhibition of FGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  16nMAssay Description:Inhibition of FLT4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataKi:  18nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM482158(TAE684 | BDBM50242742)
Affinity DataIC50: 20nMAssay Description:Inhibition of InsRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  20nMAssay Description:Inhibition of FLT3 by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 20nMAssay Description:Inhibition of ALK by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 17A(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  21nMAssay Description:Inhibition of STK17aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)
Affinity DataEC50:  21nMAssay Description:Inhibition of FGFR1 by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(Type II inhibitor, 14 | CHEMBL459850 | N-(3-(7-Ami...)
Affinity DataEC50:  22nMAssay Description:Inhibition of KDR by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  25nMAssay Description:Inhibition of TNIKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 27nMAssay Description:Inhibition of KDR by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)
Affinity DataEC50:  30nMAssay Description:Inhibition of FGFR3 by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM13534(VX680 | N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of FLT3 by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(Type II inhibitor, 14 | CHEMBL459850 | N-(3-(7-Ami...)
Affinity DataEC50:  30nMAssay Description:Inhibition of TrkC by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM12255(CHEMBL217092 | N-(5-chloro-2H-1,3-benzodioxol-4-yl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of c-AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM6190(CHEMBL189584 | 3-tert-butyl-1-(2-{[4-(diethylamino...)
Affinity DataIC50: 30nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50242740(Type II inhibitor, 14 | CHEMBL459850 | N-(3-(7-Ami...)
Affinity DataEC50:  30nMAssay Description:Inhibition of Bmx by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  35nMAssay Description:Inhibition of FLT4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetBMP-2-inducible protein kinase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  38nMAssay Description:Inhibition of BIKEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  39nMAssay Description:Inhibition of PHKG2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  40nMAssay Description:Inhibition of GakMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataKd:  41nMAssay Description:Inhibition of PDGFRbeta by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
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