Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50022204
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232529(5-(2-fluorobenzyloxy)quinazoline-2,4-diamine | CHE...)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM18050(MTX | cid_126941 | Methotrexate | 2-[(4-{[(2,4-dia...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232565(5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-d...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232535(5-(1-(3-chlorophenyl)ethoxy)quinazoline-2,4-diamin...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232534(5-((2-fluorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232589(5-((3-chlorophenoxy)methyl)quinazoline-2,4-diamine...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232538(D156844 | CHEMBL251429 | 5-((1-(2-fluorobenzyl)pip...)
Affinity DataIC50: 9.38E+3nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232526(5-((2,4-difluorophenoxy)methyl)quinazoline-2,4-dia...)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232527(5-((1-(3-chlorobenzyl)piperidin-4-yl)methoxy)quina...)
Affinity DataIC50: 5.52E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232566(5-(3-chlorobenzyloxy)quinazoline-2,4-diamine | CHE...)
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232541((3-chlorophenyl)(4-((2,4-diaminoquinazolin-5-yloxy...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232561(5-((1-(2-fluorophenylsulfonyl)piperidin-4-yl)metho...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232538(D156844 | CHEMBL251429 | 5-((1-(2-fluorobenzyl)pip...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50232571((2-chlorophenyl)(4-((2,4-diaminoquinazolin-5-yloxy...)
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of human recombinant DHFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed