Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 2517
LigandPNGBDBM21513(7-[3-(1-methylpyrrolidin-2-yl)propoxy]-4-[2-(pyrid...)
Affinity DataIC50: 72nM EC50:  17nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21506(dimethyl[2-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[...)
Affinity DataIC50: 24nM EC50:  29nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21510(dimethyl[5-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[...)
Affinity DataIC50: 47nM EC50:  24nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21505(7-(2-chloroethoxy)-4-[2-(pyridin-2-yl)-4H,5H,6H-py...)
Affinity DataIC50: 33nM EC50:  66nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21508(7-[2-(4-methylpiperazin-1-yl)ethoxy]-4-[2-(pyridin...)
Affinity DataIC50: 100nM EC50:  38nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataIC50: 59nM EC50:  40nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21504(7-[3-(4-methylpiperazin-1-yl)propoxy]-4-[2-(pyridi...)
Affinity DataIC50: 74nM EC50:  44nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21511(1-(4-methylpiperazin-1-yl)-2-({4-[2-(pyridin-2-yl)...)
Affinity DataIC50: 49nM EC50:  260nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21496(6-bromo-4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrro...)
Affinity DataIC50: 89nM EC50:  55nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21507(ethyl(methyl)[2-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyr...)
Affinity DataIC50: 85nM EC50:  61nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21509(4-[2-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]...)
Affinity DataIC50: 69nM EC50:  180nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21512(7-(oxolan-2-ylmethoxy)-4-[2-(pyridin-2-yl)-4H,5H,6...)
Affinity DataIC50: 130nM EC50:  80nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21497(4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a...)
Affinity DataIC50: 141nM EC50:  201nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21503(4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyrazol...)
Affinity DataIC50: 160nM EC50:  200nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21499(N-[2-(dimethylamino)ethyl]-4-[2-(6-methylpyridin-2...)
Affinity DataIC50: 193nM EC50:  468nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21498(methyl 4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrrol...)
Affinity DataIC50: 526nM EC50:  403nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21518(dimethyl({[4-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrol...)
Affinity DataIC50: 750nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21495(8-fluoro-4-[2-(6-methylpyridin-2-yl)-4H,5H,6H-pyrr...)
Affinity DataIC50: 928nM EC50:  951nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21515(4-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyr...)
Affinity DataIC50: 1.10E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21517(N,N-dimethyl-4-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrr...)
Affinity DataIC50: 1.10E+3nM EC50:  1.50E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21514(4-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyr...)
Affinity DataIC50: 1.20E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21494(6,8-dimethoxy-4-[2-(6-methylpyridin-2-yl)-4H,5H,6H...)
Affinity DataIC50: 3.81E+3nM EC50:  7.20E+3nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21516(4-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyr...)
Affinity DataIC50: 4.80E+3nM EC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21493(2-chloro-4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-...)
Affinity DataIC50: 1.98E+4nM EC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21500(2-methoxy-4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2...)
Affinity DataIC50: 2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21501(2-(ethylsulfanyl)-4-[2-(pyridin-2-yl)-4H,5H,6H-pyr...)
Affinity DataIC50: 2.00E+4nM EC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed
LigandPNGBDBM21502(4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyrazol...)
Affinity DataIC50: 2.00E+4nM EC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2008
Entry Details Article
PubMed