Compile Data Set for Download or QSAR
Report error Found 133 Enz. Inhib. hit(s) with all data for entry = 50026621
LigandPNGBDBM50203938((S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of [3H]NA uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262625(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-methan...)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262626(Ethanesulfonic acid biphenyl-2-ylmethyl-(S)-pyrrol...)
Affinity DataKi:  5nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262415(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-isobut...)
Affinity DataKi:  6nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262627(Propane-1-sulfonic acid biphenyl-2-ylmethyl-(S)-py...)
Affinity DataKi:  7nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262684(N-(1,1'-biphenyl-2-ylmethyl)-N',N'-dimethyl-N-[(3S...)
Affinity DataKi:  8nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262678((S)-ethyl biphenyl-2-ylmethyl(pyrrolidin-3-yl)carb...)
Affinity DataKi:  8nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203938((S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of [3H]5HT uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262679(Propane-2-sulfonic acid biphenyl-2-ylmethyl-(S)-py...)
Affinity DataKi:  10nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50203943(biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-(tetrahydr...)
Affinity DataIC50: 12nMAssay Description:Inhibition of [3H]NA uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262411((S)-N-(2,3-dichlorobenzyl)-N-(pyrrolidin-3-yl)isob...)
Affinity DataIC50: 12nMAssay Description:Inhibition of [3H]5HT uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262729(Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-carbamic a...)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262630(Biphenyl-2-ylmethyl-(R)-pyrrolidin-3-yl-carbamic a...)
Affinity DataKi:  16nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262677(Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-carbamic a...)
Affinity DataKi:  18nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262733((2-Phenoxy-benzyl)-(S)-pyrrolidin-3-yl-carbamic ac...)
Affinity DataKi:  23nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262411((S)-N-(2,3-dichlorobenzyl)-N-(pyrrolidin-3-yl)isob...)
Affinity DataIC50: 23nMAssay Description:Inhibition of [3H]NA uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262619(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-butyra...)
Affinity DataKi:  25nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262624(Pyrrolidine-1-carboxylic acid biphenyl-2-ylmethyl-...)
Affinity DataKi:  27nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262631(N-Biphenyl-2-ylmethyl-N-(R)-pyrrolidin-3-yl-methan...)
Affinity DataKi:  29nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262680(N-Biphenyl-2-ylmethyl-C,C,C-trifluoro-N-(S)-pyrrol...)
Affinity DataKi:  30nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262620(N-Biphenyl-2-ylmethyl-3-methyl-N-(S)-pyrrolidin-3-...)
Affinity DataKi:  30nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262728(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-propio...)
Affinity DataKi:  30nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262676((S)-N-(2-phenoxybenzyl)-N-(pyrrolidin-3-yl)isobuty...)
Affinity DataKi:  34nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262731((S)-Pyrrolidin-3-yl-(2-trifluoromethyl-benzyl)-car...)
Affinity DataKi:  46nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262730((2-Isopropyl-benzyl)-(S)-pyrrolidin-3-yl-carbamic ...)
Affinity DataKi:  49nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262675((S)-N-(2-(methylthio)benzyl)-N-(pyrrolidin-3-yl)is...)
Affinity DataKi:  50nMAssay Description:Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262734(1-Biphenyl-2-ylmethyl-3,3-dimethyl-1-(S)-pyrrolidi...)
Affinity DataKi:  53nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262674(N-(S)-Pyrrolidin-3-yl-N-(2-trifluoromethyl-benzyl)...)
Affinity DataKi:  63nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262675((S)-N-(2-(methylthio)benzyl)-N-(pyrrolidin-3-yl)is...)
Affinity DataKi:  65nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262621(N-(2-Isopropyl-benzyl)-N-(S)-pyrrolidin-3-yl-isobu...)
Affinity DataKi:  70nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262622(N-(2-Cyclopropyl-benzyl)-N-(S)-pyrrolidin-3-yl-iso...)
Affinity DataKi:  74nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262682(N-(2-Methylsulfanyl-benzyl)-N-(S)-pyrrolidin-3-yl-...)
Affinity DataKi:  86nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262681((S)-N-(2-(trifluoromethyl)benzyl)-N-(pyrrolidin-3-...)
Affinity DataKi:  86nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262732((2-Methylsulfanyl-benzyl)-(S)-pyrrolidin-3-yl-carb...)
Affinity DataKi:  89nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203938((S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-...)
Affinity DataIC50: 89nMAssay Description:Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262683(N-(2-Phenoxy-benzyl)-N-(S)-pyrrolidin-3-yl-methane...)
Affinity DataKi:  96nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203943(biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-(tetrahydr...)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262726(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-formam...)
Affinity DataKi:  118nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262727(N-Biphenyl-2-ylmethyl-N-(S)-pyrrolidin-3-yl-acetam...)
Affinity DataKi:  124nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262622(N-(2-Cyclopropyl-benzyl)-N-(S)-pyrrolidin-3-yl-iso...)
Affinity DataKi:  124nMAssay Description:Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262674(N-(S)-Pyrrolidin-3-yl-N-(2-trifluoromethyl-benzyl)...)
Affinity DataKi:  133nMAssay Description:Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262627(Propane-1-sulfonic acid biphenyl-2-ylmethyl-(S)-py...)
Affinity DataIC50: 185nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262676((S)-N-(2-phenoxybenzyl)-N-(pyrrolidin-3-yl)isobuty...)
Affinity DataKi:  229nMAssay Description:Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50262725(Biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-amine | CH...)
Affinity DataKi:  271nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262630(Biphenyl-2-ylmethyl-(R)-pyrrolidin-3-yl-carbamic a...)
Affinity DataIC50: 350nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262679(Propane-2-sulfonic acid biphenyl-2-ylmethyl-(S)-py...)
Affinity DataIC50: 350nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262732((2-Methylsulfanyl-benzyl)-(S)-pyrrolidin-3-yl-carb...)
Affinity DataKi:  353nMAssay Description:Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203943(biphenyl-2-ylmethyl-(S)-pyrrolidin-3-yl-(tetrahydr...)
Affinity DataIC50: 400nMAssay Description:Inhibition of [3H]5HT uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262630(Biphenyl-2-ylmethyl-(R)-pyrrolidin-3-yl-carbamic a...)
Affinity DataKi:  410nMAssay Description:Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262620(N-Biphenyl-2-ylmethyl-3-methyl-N-(S)-pyrrolidin-3-...)
Affinity DataKi:  415nMAssay Description:Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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