Compile Data Set for Download or QSAR
Report error Found 135 Enz. Inhib. hit(s) with all data for entry = 50031858
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16735BDBM16735(N-(2-{4-[(3R)-3-hydroxy-3-phenylpropyl]piperazin-1...)
Affinity DataIC50: 46nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16733BDBM16733(N-{2-[4-(5-aminopentyl)piperazin-1-yl]-5-phenylphe...)
Affinity DataIC50: 68nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16734BDBM16734(N-(2-{4-[(3S)-3-hydroxy-3-phenylpropyl]piperazin-1...)
Affinity DataIC50: 69nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16736BDBM16736(N-[2-(4-benzoylpiperazin-1-yl)-5-phenylphenyl]naph...)
Affinity DataIC50: 79nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16727BDBM16727(N-{5-bromo-2-[4-(2-hydroxyethyl)piperazin-1-yl]phe...)
Affinity DataIC50: 79nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16731BDBM16731(ethyl 2-{4-[2-(naphthalene-1-amido)-4-phenylphenyl...)
Affinity DataIC50: 90nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16732BDBM16732(N-(2-{4-[5-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16730BDBM16730(N-{2-[4-(2-hydroxyethyl)piperazin-1-yl]-5-phenylph...)
Affinity DataIC50: 110nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16749BDBM16749(N-[2-(4-benzylpiperazin-1-yl)-5-phenylphenyl]-2-ox...)
Affinity DataIC50: 151nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16729BDBM16729(N-[5-phenyl-2-(piperazin-1-yl)phenyl]naphthalene-1...)
Affinity DataIC50: 300nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16750BDBM16750(CHEMBL1164612 | 2,2,2-trifluoroacetic acid; 2-oxo-...)
Affinity DataIC50: 580nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16742BDBM16742(N-{5-bromo-2-[4-(2-hydroxyethyl)piperazin-1-yl]phe...)
Affinity DataIC50: 630nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16741BDBM16741(2,2,2-trifluoroacetic acid; N-[5-bromo-2-(piperazi...)
Affinity DataIC50: 670nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16740BDBM16740(CHEMBL206442 | N-[2-(4-benzylpiperazin-1-yl)-5-bro...)
Affinity DataIC50: 760nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16739BDBM16739(CHEMBL207083 | tert-butyl 4-{4-bromo-2-[(2-oxo-2H-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16747BDBM16747(N-{5-bromo-2-[4-(2-hydroxyethyl)piperazin-1-yl]phe...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16744BDBM16744(tert-butyl 4-{4-bromo-2-[(8-methoxy-2-oxo-2H-chrom...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16724BDBM16724(CHEMBL381618 | tert-butyl 4-[4-bromo-2-(naphthalen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16726BDBM16726(N-[5-bromo-2-(piperazin-1-yl)phenyl]naphthalene-1-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320690BDBM50320690(1-{[3-(4-Chloro-phenylcarbamoyl)-phenylcarbamoyl]-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16728BDBM16728(N-[2-(4-benzylpiperazin-1-yl)-5-phenylphenyl]napht...)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16046BDBM16046(oxyacetamide 5 | 3-{[(5-aminopentyl)carbamoyl]meth...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320694BDBM50320694(3-Carbamoyl-1-{[3-(4-methoxy-phenylcarbamoyl)-phen...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320698BDBM50320698(1-{[3-(4-Methyl-benzoylamino)-phenylcarbamoyl]-met...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16044BDBM16044(3-{[(5-aminopentyl)carbamoyl]methoxy}-5-{[(1R)-1-p...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320691BDBM50320691(1-{[3-(4-Methoxy-phenylcarbamoyl)-phenylcarbamoyl]...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320600BDBM50320600(1-{4-(4'-chlorophenyl)-2-[(naphthalene-1-carbonyl)...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320696BDBM50320696(3-Phenethylcarbamoyl-1-[(3-p-tolylcarbamoyl-phenyl...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16746BDBM16746(CHEMBL206557 | CHEMBL1165583 | 2,2,2-trifluoroacet...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16745BDBM16745(CHEMBL381617 | N-[2-(4-benzylpiperazin-1-yl)-5-bro...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16725BDBM16725(N-[2-(4-benzylpiperazin-1-yl)-5-bromophenyl]naphth...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320629BDBM50320629(2-chloro-5-(5-((2-(4-(4-fluorophenylamino)-6-morph...)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16738BDBM16738(N-[5-bromo-2-(morpholin-4-yl)phenyl]-2-oxo-2H-chro...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16743BDBM16743(N-[5-bromo-2-(morpholin-4-yl)phenyl]-8-methoxy-2-o...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16409BDBM16409(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320606BDBM50320606(2-((2-(4,6-bis(phenylamino)-1,3,5-triazin-2-yl)hyd...)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320618BDBM50320618(4-ethoxy-6-(2-(4-iodo-2-methylphenyl)hydrazinyl)-N...)
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320697BDBM50320697(1-{[3-(4-Chloro-phenylcarbamoyl)-phenylcarbamoyl]-...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320692BDBM50320692(1{[3-(4-Methyl-benzoylamino)-phenylcarbamoyl]-meth...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16414BDBM16414(1-N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phen...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16034BDBM16034(N-[(1S,2R)-1-benzyl-3-(cyclopropylamino)-2-hydroxy...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16412BDBM16412(1-N-[(2S,3R)-4-(tert-butylamino)-3-hydroxy-1-pheny...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16411BDBM16411(1-N-[(2S,3R)-4-(ethylamino)-3-hydroxy-1-phenylbuta...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16723BDBM16723(N-[5-bromo-2-(morpholin-4-yl)phenyl]naphthalene-1-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320613BDBM50320613(2,4-dibromo-6-((2-(4-(3-chloro-4-methylphenylamino...)
Affinity DataIC50: 2.06E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16043BDBM16043(3-{[(5-aminopentyl)carbamoyl]methoxy}-5-(2-cyanoph...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16410BDBM16410(1-N-[(2S,3R)-4-amino-3-hydroxy-1-phenylbutan-2-yl]...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320632BDBM50320632((R)-5-(2-(5-aminopentylamino)-2-oxoethoxy)-N1-(1-p...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320610BDBM50320610(2-((2-(4,6-bis(phenylamino)-1,3,5-triazin-2-yl)hyd...)
Affinity DataIC50: 2.55E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Applied Science University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50320626BDBM50320626(5-(5-((2-(4-(4-fluorophenylamino)-6-(piperidin-1-y...)
Affinity DataIC50: 2.79E+4nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
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