Compile Data Set for Download or QSAR
maximum 50k data
Found 52 Enz. Inhib. hit(s) with all data for entry = 50032016
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323359((S)-2-{6-[(S)-1-(4-Chloro-phenyl)-ethyl]-5,5-dioxo...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323356(6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-isopropoxymeth...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323355(6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-(2-methoxy-2-m...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323357(6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-cyclopropylmet...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50047262((R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-y...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323360(4-(7-benzyl-6-oxo-5,6,7,8-tetrahydroimidazo[1,5-a]...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323358((R)-2-{6-[(S)-1-(4-Chloro-phenyl)-ethyl]-5,5-dioxo...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323342(6-(4-Fluoro-benzyl)-4-isobutyl-6,7-dihydro-5-thia-...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323343(6-(4-Chloro-benzyl)-4-isobutyl-6,7-dihydro-5-thia-...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323354(6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-(3-methyl-oxet...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323351(6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-isobutyl-6,7-d...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50047262((R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-y...)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323353(1-{6-[(S)-1-(4-Chloro-phenyl)-ethyl]-5,5-dioxo-4,5...)
Affinity DataIC50:  11.4nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323344(6-Benzyl-4-isobutyl-6,7-dihydro-5-thia-2,3a,6-tria...)
Affinity DataIC50:  18.6nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323355(6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-(2-methoxy-2-m...)
Affinity DataIC50:  20.6nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323342(6-(4-Fluoro-benzyl)-4-isobutyl-6,7-dihydro-5-thia-...)
Affinity DataIC50:  26.1nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323360(4-(7-benzyl-6-oxo-5,6,7,8-tetrahydroimidazo[1,5-a]...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323343(6-(4-Chloro-benzyl)-4-isobutyl-6,7-dihydro-5-thia-...)
Affinity DataIC50:  50.2nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323349(4-Isobutyl-6-thiophen-2-ylmethyl-6,7-dihydro-5-thi...)
Affinity DataIC50:  55.7nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323352(6-[(R)-1-(4-Chloro-phenyl)-ethyl]-4-isobutyl-6,7-d...)
Affinity DataIC50:  61.7nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323351(6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-isobutyl-6,7-d...)
Affinity DataIC50:  76nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323343(6-(4-Chloro-benzyl)-4-isobutyl-6,7-dihydro-5-thia-...)
Affinity DataIC50:  87nMAssay Description:Inhibition of human CYP3A4-mediated testosterone oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323344(6-Benzyl-4-isobutyl-6,7-dihydro-5-thia-2,3a,6-tria...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human CYP3A4-mediated midazolam oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323358((R)-2-{6-[(S)-1-(4-Chloro-phenyl)-ethyl]-5,5-dioxo...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human CYP3A4-mediated midazolam oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323344(6-Benzyl-4-isobutyl-6,7-dihydro-5-thia-2,3a,6-tria...)
Affinity DataIC50:  103nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323345(4-Isobutyl-6-(4-trifluoromethoxy-benzyl)-6,7-dihyd...)
Affinity DataIC50:  104nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323349(4-Isobutyl-6-thiophen-2-ylmethyl-6,7-dihydro-5-thi...)
Affinity DataIC50:  117nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323350(6-[1-(4-Chloro-phenyl)-cyclopropyl]-4-isobutyl-6,7...)
Affinity DataIC50:  119nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323356(6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-isopropoxymeth...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human CYP3A4-mediated testosterone oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323346(CHEMBL1209556 | rac-4-Isobutyl-6-(4-trifluoromethy...)
Affinity DataIC50:  121nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323348(6-Cyclopropylmethyl-4-isobutyl-6,7-dihydro-5-thia-...)
Affinity DataIC50:  122nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323357(6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-cyclopropylmet...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human CYP3A4-mediated testosterone oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323359((S)-2-{6-[(S)-1-(4-Chloro-phenyl)-ethyl]-5,5-dioxo...)
Affinity DataIC50:  182nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323352(6-[(R)-1-(4-Chloro-phenyl)-ethyl]-4-isobutyl-6,7-d...)
Affinity DataIC50:  204nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323356(6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-isopropoxymeth...)
Affinity DataIC50:  222nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323358((R)-2-{6-[(S)-1-(4-Chloro-phenyl)-ethyl]-5,5-dioxo...)
Affinity DataIC50:  234nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323357(6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-cyclopropylmet...)
Affinity DataIC50:  245nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323346(CHEMBL1209556 | rac-4-Isobutyl-6-(4-trifluoromethy...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human CYP3A4-mediated testosterone oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323354(6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-(3-methyl-oxet...)
Affinity DataIC50:  340nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323353(1-{6-[(S)-1-(4-Chloro-phenyl)-ethyl]-5,5-dioxo-4,5...)
Affinity DataIC50:  471nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323345(4-Isobutyl-6-(4-trifluoromethoxy-benzyl)-6,7-dihyd...)
Affinity DataIC50:  490nMAssay Description:Inhibition of human CYP3A4-mediated testosterone oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323355(6-[(S)-1-(4-Chloro-phenyl)-ethyl]-4-(2-methoxy-2-m...)
Affinity DataIC50:  530nMAssay Description:Inhibition of human CYP3A4-mediated testosterone oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323345(4-Isobutyl-6-(4-trifluoromethoxy-benzyl)-6,7-dihyd...)
Affinity DataIC50:  544nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323346(CHEMBL1209556 | rac-4-Isobutyl-6-(4-trifluoromethy...)
Affinity DataIC50:  566nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323350(6-[1-(4-Chloro-phenyl)-cyclopropyl]-4-isobutyl-6,7...)
Affinity DataIC50:  628nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323348(6-Cyclopropylmethyl-4-isobutyl-6,7-dihydro-5-thia-...)
Affinity DataIC50:  758nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323358((R)-2-{6-[(S)-1-(4-Chloro-phenyl)-ethyl]-5,5-dioxo...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human CYP3A4-mediated testosterone oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323347(6-Cyclopropyl-4-isobutyl-6,7-dihydro-5-thia-2,3a,6...)
Affinity DataIC50:  930nMAssay Description:Inhibition of human recombinant CYP11B1 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323347(6-Cyclopropyl-4-isobutyl-6,7-dihydro-5-thia-2,3a,6...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human recombinant CYP11B2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50323349(4-Isobutyl-6-thiophen-2-ylmethyl-6,7-dihydro-5-thi...)
Affinity DataIC50:  1.16E+3nMAssay Description:Inhibition of human CYP3A4-mediated testosterone oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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