Compile Data Set for Download or QSAR
maximum 50k data
Found 68 Enz. Inhib. hit(s) with all data for entry = 50032427
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329079(CHEMBL1270280 | N2-(2,6-dimorpholinopyridin-4-yl)-...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329070(CHEMBL1269858 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329080(CHEMBL1270378 | N2-(2,6-dimorpholinopyrimidin-4-yl...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50293247(CHEMBL468970 | N4-(5-chlorobenzo[d][1,3]dioxol-4-y...)
Affinity DataIC50:  4nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329079(CHEMBL1270280 | N2-(2,6-dimorpholinopyridin-4-yl)-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329070(CHEMBL1269858 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  9nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329065(CHEMBL1271187 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  11nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329076(CHEMBL1270182 | N-(3-(4-((1H-indazol-4-yl)(methyl)...)
Affinity DataIC50:  13nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50293247(CHEMBL468970 | N4-(5-chlorobenzo[d][1,3]dioxol-4-y...)
Affinity DataIC50:  14nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329072((3-(4-((1H-indazol-4-yl)(methyl)amino)pyrimidin-2-...)
Affinity DataIC50:  21nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329080(CHEMBL1270378 | N2-(2,6-dimorpholinopyrimidin-4-yl...)
Affinity DataIC50:  24nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM25226(2,4-Pyrimidine derivative, 28 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  25nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329074(3-(4-((1H-indazol-4-yl)(methyl)amino)pyrimidin-2-y...)
Affinity DataIC50:  29nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329053(CHEMBL1270569 | N4-(benzo[d][1,3]dioxol-4-yl)-N2-(...)
Affinity DataIC50:  34nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329061(CHEMBL1270976 | N4-(5-chlorobenzo[d][1,3]dioxol-4-...)
Affinity DataIC50:  36nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329069(CHEMBL1271394 | N4-(1H-indazol-4-yl)-N4-methyl-N2-...)
Affinity DataIC50:  36nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329061(CHEMBL1270976 | N4-(5-chlorobenzo[d][1,3]dioxol-4-...)
Affinity DataIC50:  42nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329069(CHEMBL1271394 | N4-(1H-indazol-4-yl)-N4-methyl-N2-...)
Affinity DataIC50:  51nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329078(CHEMBL1270279 | N4-(3-chloro-1H-indazol-4-yl)-N2-(...)
Affinity DataIC50:  55nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329070(CHEMBL1269858 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  58nMAssay Description:Inhibition of PDGFRbeta phosphorylation in human MG63 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329059(CHEMBL1236772 | GTC000121A | N4-(1H-indazol-4-yl)-...)
Affinity DataIC50:  61nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329077(CHEMBL1270183 | N2-(3,5-dimorpholinophenyl)-N4-(3-...)
Affinity DataIC50:  67nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329075(CHEMBL1270076 | GTC000161A | N-(3-(4-(1H-indazol-4...)
Affinity DataIC50:  84nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329066(CHEMBL1271287 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  89nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329062(2-((5-chlorobenzo[d][1,3]dioxol-4-yl)(2-(3-(methyl...)
Affinity DataIC50:  95nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329068(CHEMBL1271393 | N4-(1H-benzo[d][1,2,3]triazol-4-yl...)
Affinity DataIC50:  115nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329067(CHEMBL1271288 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  117nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329064(2-((5-chlorobenzo[d][1,3]dioxol-4-yl)(2-(3-(methyl...)
Affinity DataIC50:  121nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329053(CHEMBL1270569 | N4-(benzo[d][1,3]dioxol-4-yl)-N2-(...)
Affinity DataIC50:  186nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM25226(2,4-Pyrimidine derivative, 28 | 4-N-(5-chloro-2H-1...)
Affinity DataIC50:  187nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329064(2-((5-chlorobenzo[d][1,3]dioxol-4-yl)(2-(3-(methyl...)
Affinity DataIC50:  187nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329062(2-((5-chlorobenzo[d][1,3]dioxol-4-yl)(2-(3-(methyl...)
Affinity DataIC50:  190nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329071((3-(4-(1H-indazol-4-ylamino)pyrimidin-2-ylamino)ph...)
Affinity DataIC50:  204nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329055(CHEMBL1270671 | N4-(benzofuran-7-yl)-N2-(3-(methyl...)
Affinity DataIC50:  205nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329057(CHEMBL1270773 | N4-(benzo[d]oxazol-7-yl)-N2-(3-(me...)
Affinity DataIC50:  219nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329078(CHEMBL1270279 | N4-(3-chloro-1H-indazol-4-yl)-N2-(...)
Affinity DataIC50:  227nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329072((3-(4-((1H-indazol-4-yl)(methyl)amino)pyrimidin-2-...)
Affinity DataIC50:  232nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329070(CHEMBL1269858 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  240nMAssay Description:Inhibition of KDR phosphorylation in HUVECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329073(3-(4-(1H-indazol-4-ylamino)pyrimidin-2-ylamino)-N,...)
Affinity DataIC50:  246nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329063(CHEMBL1271082 | N4-(5-chlorobenzo[d][1,3]dioxol-4-...)
Affinity DataIC50:  246nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329054(CHEMBL1270670 | N4-(6-chlorobenzofuran-7-yl)-N2-(3...)
Affinity DataIC50:  300nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329065(CHEMBL1271187 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  302nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329063(CHEMBL1271082 | N4-(5-chlorobenzo[d][1,3]dioxol-4-...)
Affinity DataIC50:  378nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329081(CHEMBL1270379 | N2-(4,6-dimorpholinopyrimidin-2-yl...)
Affinity DataIC50:  432nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329074(3-(4-((1H-indazol-4-yl)(methyl)amino)pyrimidin-2-y...)
Affinity DataIC50:  453nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329055(CHEMBL1270671 | N4-(benzofuran-7-yl)-N2-(3-(methyl...)
Affinity DataIC50:  460nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329077(CHEMBL1270183 | N2-(3,5-dimorpholinophenyl)-N4-(3-...)
Affinity DataIC50:  513nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329058(CHEMBL1270874 | N4-(benzo[d]oxazol-4-yl)-N2-(3-(me...)
Affinity DataIC50:  549nMAssay Description:Inhibition of EphB4 by acoustic dispensing assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329067(CHEMBL1271288 | N2-(3,5-dimorpholinophenyl)-N4-(1H...)
Affinity DataIC50:  856nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50329054(CHEMBL1270670 | N4-(6-chlorobenzofuran-7-yl)-N2-(3...)
Affinity DataIC50:  897nMAssay Description:Inhibition of EphB4 autophosphorylation expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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