Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50033283
TargetHistone deacetylase 2(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342750(N,8-dihydroxy-8-(2-(4-(prop-2-ynyloxy)benzylidene)...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342750(N,8-dihydroxy-8-(2-(4-(prop-2-ynyloxy)benzylidene)...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342752(3-(2-(3-(((R)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...)
Affinity DataIC50: 23nMAssay Description:Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342751(N-hydroxy-3-(2-(4-(prop-2-ynyloxy)benzylidene)hydr...)
Affinity DataIC50: 29nMAssay Description:Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 34nMAssay Description:Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342749(3-(2-benzylidenehydrazinecarbonyl)-N-hydroxybenzam...)
Affinity DataIC50: 52nMAssay Description:Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 66nMAssay Description:Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 8(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342753(3-(2-(3-(((S)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...)
Affinity DataIC50: 110nMAssay Description:Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342750(N,8-dihydroxy-8-(2-(4-(prop-2-ynyloxy)benzylidene)...)
Affinity DataIC50: 290nMAssay Description:Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of full length HDAC8 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 2(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342752(3-(2-(3-(((R)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342753(3-(2-(3-(((S)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342751(N-hydroxy-3-(2-(4-(prop-2-ynyloxy)benzylidene)hydr...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342751(N-hydroxy-3-(2-(4-(prop-2-ynyloxy)benzylidene)hydr...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342752(3-(2-(3-(((R)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342753(3-(2-(3-(((S)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclo...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342749(3-(2-benzylidenehydrazinecarbonyl)-N-hydroxybenzam...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of full length HDAC3/NCoR2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Howard Hughes Medical Institute

Curated by ChEMBL
LigandPNGBDBM50342749(3-(2-benzylidenehydrazinecarbonyl)-N-hydroxybenzam...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of full length HDAC2 assessed as 7-amino-4-methylcoumarin release from fluorophore conjugated substrate after 5 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed