Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50045715
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50080337((R)-1-{2-[2,2-Bis-(3-methyl-thiophen-2-yl)-vinylox...)
Affinity DataIC50: 10nMAssay Description:Inhibition of rat brain synaptosomes GAT1 assessed as inhibition of [3H]GABA uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50426072(CHEMBL1190520)
Affinity DataIC50: 60nMAssay Description:Inhibition of rat brain synaptosomes GAT1 assessed as inhibition of [3H]GABA uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataIC50: 70nMAssay Description:Inhibition of rat brain synaptosomes GAT1 assessed as inhibition of [3H]GABA uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50080346((R)-1-(2-Benzhydrylideneaminooxy-ethyl)-piperidine...)
Affinity DataIC50: 80nMAssay Description:Inhibition of rat brain synaptosomes GAT1 assessed as inhibition of [3H]GABA uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataIC50: 640nMAssay Description:Inhibition of rat GAT1 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50081886((R)-1-(6,6-Diphenyl-hexyl)-piperidine-3-carboxylic...)
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of rat brain synaptosomes GAT1 assessed as inhibition of [3H]GABA uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50078167(CHEMBL69064)
Affinity DataIC50: 1.92E+3nMAssay Description:Inhibition of rat brain synaptosomes GAT1 assessed as inhibition of [3H]GABA uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50078168(CHEMBL3417707)
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of rat brain synaptosomes GAT1 assessed as inhibition of [3H]GABA uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
University of Vienna

Curated by ChEMBL
LigandPNGBDBM50078169(CHEBI:28774 | Reverse triiodothyronine | REVERSETR...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of rat GAT1 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2016
Entry Details Article
PubMed