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Found 13 Enz. Inhib. hit(s) with all data for entry = 50047014
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM109106(US8609852, 13)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine from mGlu5R in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM109136(US8609852, 43)
Affinity DataKi:  0.650nMAssay Description:Displacement of [3H]methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine from mGlu5R in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 StaR domain (569 to 836 residues) (unknown origin) expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50443085(AFQ056 | Mavoglurant)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 StaR domain (569 to 836 residues) (unknown origin) expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50143540(CHEMBL3759750)
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]methoxy-PEPgamma from mGluR5 in rat cerebral cortex membranes after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50154977(2-{2-[3-fluoro-5-(pyridin-3-yloxy)phenyl]-2H-tetra...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5R in rat cortical membranes by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50122758(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5R in rat cortical membranes by liquid scintillation spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50143544(CHEMBL3759766)
Affinity DataIC50:  0.790nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as inhibition of glutamate-induced effect by aequorin bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50143541(CHEMBL3759977)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at human mGluR5d by fluo-3-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50143542(CHEMBL3758851)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]-MPEP (2-methyl-6-(phenylethynyl)pyridine) from mGlu5R in Sprague-Dawley rat cortical membranes after 60 mins by scintillation co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50143539(CHEMBL3758266)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at mGluR5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50143538(CHEMBL3759888)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human mGluR5d by fluo-3-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50143543(CHEMBL3759200)
Affinity DataIC50:  91nMAssay Description:Antagonist activity at rat mGluR5 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization by Fluo-4 dye-based fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed