Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50047582
TargetVascular endothelial growth factor receptor 1(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM24773(N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...)
Affinity DataIC50: 2nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM24773(N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyr...)
Affinity DataIC50: 3nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50176995(CHEMBL3814018)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant MMP13 (85 to 255 residues) expressed in Escherichia coli using 5-FAM/QXLTM as substrate by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50386750(CHEMBL2046699)
Affinity DataIC50: 7nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK as substrate after 40 mins by scintillation counting method in presence of [gamma-33P-ATP]More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50176993(CHEMBL3815076)
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]-17beta-estradiol from human recombinant ERalpha expressed in rabbit reticulocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50176973(CHEMBL3814827)
Affinity DataIC50: 50nMAssay Description:Inhibition of inactivated PLK1 in human HeLa cells using casein as substrate by immunoprecipitation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50176996(CHEMBL3813969)
Affinity DataKi:  64nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D2(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM6655(3-(9-oxo-9H-fluoren-4-yl)-1-pyridin-2-ylurea | N-(...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant CDK4/Cyclin D2 expressed in baculovirus infected insect Sf9 cells using G1 peptide as substrate after 45 mins by Top ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMed
TargetProtease(Human immunodeficiency virus type 1)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50176992(CHEMBL3814142)
Affinity DataIC50: 160nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50176993(CHEMBL3815076)
Affinity DataIC50: 190nMAssay Description:Displacement of [3H]-17beta-estradiol from human recombinant ERbeta expressed in rabbit reticulocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50176996(CHEMBL3813969)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50176998(CHEMBL3814434)
Affinity DataEC50:  6.00E+3nMAssay Description:Inhibition of human recombinant PDE3B expressed in insect Sf9 cells assessed as residual cAMP level after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Swiss Federal Institute of Technology (Eth)

Curated by ChEMBL
LigandPNGBDBM50176994(CHEMBL3813784)
Affinity DataEC50:  6.00E+3nMAssay Description:Activation of human liver cathepsin L using Z-FR-AMC as substrate measured for 120 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2017
Entry Details Article
PubMed