Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50018885
TargetPoly [ADP-ribose] polymerase 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 207624BDBM207624(US9260440, 69 | US9617273, Example 69 | US10501467...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of PARP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50084621BDBM50084621(BMN 673 | Talazoparib | US12427157, Example R8H-15)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of human recombinant PARP-1 (662 to 1011 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 207624BDBM207624(US9260440, 69 | US9617273, Example 69 | US10501467...)
Affinity DataIC50: 0.830nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 139658BDBM139658(US8894989, 37)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant PARP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Mouse)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 139658BDBM139658(US8894989, 37)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of mouse recombinant PARP-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50536939BDBM50536939(CHEMBL4569417)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human PARP-1 using histone as substrate incubated for 16 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50536939BDBM50536939(CHEMBL4569417)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human PARP-2 using histone as substrate incubated for 16 hrs by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50446130BDBM50446130(AG-014699 | AG-14447 | Rucaparib | RUCAPARIB CAMSY...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human full-length recombinant PARP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50288530BDBM50288530(CHEMBL4098253)
Affinity DataIC50: 5nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50613638BDBM50613638(Cep 9722 | Cep-9722 | CEP-9722)
Affinity DataIC50: 6nMAssay Description:Inhibition of PARP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50613639BDBM50613639(CHEMBL190434)
Affinity DataIC50: 15nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Bovine)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27709BDBM27709(CHEMBL401843 | 2-{3-[4-(4-fluorophenyl)-1,2,3,6-te...)
Affinity DataIC50: 16nMAssay Description:Inhibition of calf thymus PARP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50613638BDBM50613638(Cep 9722 | Cep-9722 | CEP-9722)
Affinity DataIC50: 20nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27496BDBM27496((4Z)-4-[(1-methyl-1H-pyrrol-2-yl)methylidene]-1,2,...)
Affinity DataIC50: 45nMAssay Description:Inhibition of human PARP-1 incubated for 18 to 20 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 97563BDBM97563(US8470825, 4i)
Affinity DataKi:  50nMAssay Description:Inhibition of PARP-1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Mouse)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341861BDBM50341861(5-Benzamidoisoquinolin-1-one | CHEMBL1767054)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of mouse recombinant PARP-2 incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Mouse)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50341861BDBM50341861(5-Benzamidoisoquinolin-1-one | CHEMBL1767054)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of mouse recombinant PARP-1 incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 27496BDBM27496((4Z)-4-[(1-methyl-1H-pyrrol-2-yl)methylidene]-1,2,...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human PARP-2 incubated for 18 to 20 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50106185BDBM50106185(2H-Phthalazin-1-one | CHEMBL124706)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50613637BDBM50613637(INIPARIB | Iniparib | BSI-201)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human PARP-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed