Compile Data Set for Download or QSAR
Report error Found 122 Enz. Inhib. hit(s) with all data for entry = 50047981
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50007518BDBM50007518(3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmet...)
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]N-methylspiperone from human D3R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50007518BDBM50007518(3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmet...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]N-methylspiperone from human D2R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50336892BDBM50336892((R)-Modafinil | CHEMBL1201192 | Nuvigil | ARMODAFI...)
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at DRD2 (unknown origin) expressed in HEK293T cells transfected with Galphai1-RLuc8 and gamma2-GFP10 assessed as inhibition of qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50061885BDBM50061885(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-butyl-8-aza-bi...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in whole-guinea pig brain minus cerebellum homogenates incubated for 120 mins by radioligand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199786BDBM50199786(CHEMBL3918282)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199800BDBM50199800(CHEMBL3979590 | US9862679, Compound 9g | US1091371...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199798BDBM50199798(CHEMBL3941865)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199791BDBM50199791(CHEMBL3894678)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199809BDBM50199809(CHEMBL3890247)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199854BDBM50199854(CHEMBL3952924 | US9862679, Compound 7a | US1091371...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199790BDBM50199790(CHEMBL3916231 | US9862679, Compound 9d | US1091371...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in whole-guinea pig brain minus cerebellum homogenates incubated for 120 mins by radioligand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199713BDBM50199713(CHEMBL3965237 | US9862679, Compound 7b | US1091371...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199855BDBM50199855(CHEMBL3907263)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199786BDBM50199786(CHEMBL3918282)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]WIN35,428 from wild type human DAT expressed in COS7 cell membranes incubated for >90 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199795BDBM50199795(CHEMBL3909363 | US9862679, Compound 9j | US1091371...)
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199853BDBM50199853(CHEMBL3935199)
Affinity DataKi:  7.40nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199799BDBM50199799(CHEMBL3971463)
Affinity DataKi:  7.60nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199808BDBM50199808(CHEMBL3923939)
Affinity DataKi:  9.70nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50061885BDBM50061885(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-butyl-8-aza-bi...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199786BDBM50199786(CHEMBL3918282)
Affinity DataKi:  12nMAssay Description:Inhibition of DAT (unknown origin) expressed in COS7 cells assessed as reduction in [3H]DA uptake incubated for 5 mins by beta-scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199790BDBM50199790(CHEMBL3916231 | US9862679, Compound 9d | US1091371...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199850BDBM50199850(CHEMBL3931813)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199720BDBM50199720(CHEMBL3959292)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199736BDBM50199736(CHEMBL3904892)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199792BDBM50199792(CHEMBL3126735 | US9862679, Compound 4g | US1091371...)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]N-methylspiperone from human D4R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199801BDBM50199801(CHEMBL3927228)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199787BDBM50199787(CHEMBL3889802)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50061885BDBM50061885(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-butyl-8-aza-bi...)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]N-methylspiperone from human D3R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199804BDBM50199804(CHEMBL3890835)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199852BDBM50199852(CHEMBL3895932)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199810BDBM50199810(CHEMBL3899193 | US9862679, Compound 12a | US109137...)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50061885BDBM50061885(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-butyl-8-aza-bi...)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]WIN35,428 from wild type human DAT expressed in COS7 cell membranes incubated for >90 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199806BDBM50199806(CHEMBL3944169 | US9862679, Compound 9a | US1091371...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199803BDBM50199803(CHEMBL3957984)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199788BDBM50199788(CHEMBL3944646)
Affinity DataKi:  56nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199856BDBM50199856(CHEMBL3979186)
Affinity DataKi:  59nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199792BDBM50199792(CHEMBL3126735 | US9862679, Compound 4g | US1091371...)
Affinity DataKi:  66nMAssay Description:Displacement of [3H]N-methylspiperone from human D3R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50061885BDBM50061885(3-[Bis-(4-fluoro-phenyl)-methoxy]-8-butyl-8-aza-bi...)
Affinity DataKi:  68nMAssay Description:Displacement of [3H]N-methylspiperone from human D2R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50007518BDBM50007518(3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmet...)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]N-methylspiperone from human D4R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199848BDBM50199848(CHEMBL3970990)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199786BDBM50199786(CHEMBL3918282)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]N-methylspiperone from human D2R expressed in HEK293 cell membranes incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199790BDBM50199790(CHEMBL3916231 | US9862679, Compound 9d | US1091371...)
Affinity DataKi:  101nMAssay Description:Displacement of [3H]WIN35,428 from wild type human DAT expressed in COS7 cell membranes incubated for >90 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199792BDBM50199792(CHEMBL3126735 | US9862679, Compound 4g | US1091371...)
Affinity DataKi:  116nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199797BDBM50199797(CHEMBL3950591)
Affinity DataKi:  143nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199792BDBM50199792(CHEMBL3126735 | US9862679, Compound 4g | US1091371...)
Affinity DataKi:  159nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in whole-guinea pig brain minus cerebellum homogenates incubated for 120 mins by radioligand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22418BDBM22418(Cocaine (-) | methyl (1R,2R,3S,5S)-3-(benzoyloxy)-...)
Affinity DataKi:  200nMAssay Description:Inhibition of DAT (unknown origin) expressed in COS7 cells assessed as reduction in [3H]DA uptake incubated for 5 mins by beta-scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199790BDBM50199790(CHEMBL3916231 | US9862679, Compound 9d | US1091371...)
Affinity DataKi:  200nMAssay Description:Inhibition of DAT (unknown origin) expressed in COS7 cells assessed as reduction in [3H]DA uptake incubated for 5 mins by beta-scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199795BDBM50199795(CHEMBL3909363 | US9862679, Compound 9j | US1091371...)
Affinity DataKi:  213nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat brain stem membranes incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50199802BDBM50199802(CHEMBL3908243)
Affinity DataKi:  214nMAssay Description:Displacement of [3H]WIN35,428 from DAT in Sprague-Dawley rat brain membranes incubated for 120 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22418BDBM22418(Cocaine (-) | methyl (1R,2R,3S,5S)-3-(benzoyloxy)-...)
Affinity DataKi:  223nMAssay Description:Displacement of [3H]WIN35,428 from wild type human DAT expressed in COS7 cell membranes incubated for >90 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2018
Entry Details Article
PubMed
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