Compile Data Set for Download or QSAR
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Found 8 Enz. Inhib. hit(s) with all data for entry = 7824
TargetSRSF protein kinase 1(Homo sapiens (Human))
Exonate

LigandPNGBDBM221074(SPHINX31 | US9695160, 12 | US9796707, Compound 12)
Affinity DataIC50:  5.90nMpH: 7.5 T: 2°CAssay Description:A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...More data for this Ligand-Target Pair
TargetSRSF protein kinase 1(Homo sapiens (Human))
Exonate

LigandPNGBDBM221074(SPHINX31 | US9695160, 12 | US9796707, Compound 12)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...More data for this Ligand-Target Pair
TargetSRSF protein kinase 1(Homo sapiens (Human))
Exonate

LigandPNGBDBM221072(SPHINX scaffold, 2)
Affinity DataIC50:  20nMpH: 7.5 T: 2°CAssay Description:A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSRSF protein kinase 1(Homo sapiens (Human))
Exonate

LigandPNGBDBM221071(SPHINX scaffold, 1)
Affinity DataIC50:  31nMpH: 7.5 T: 2°CAssay Description:A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Exonate

LigandPNGBDBM221073(SPHINX scaffold, 3 | US9695160, SPHINX7 | US979670...)
Affinity DataIC50:  36nMpH: 7.45 T: 2°CAssay Description:Whole cell patch clamp recordings of hERG current (IhERG) were made at 37 °C from human embryonic kidney cells (HEK 293) cells stably expressing ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSRSF protein kinase 1(Homo sapiens (Human))
Exonate

LigandPNGBDBM221073(SPHINX scaffold, 3 | US9695160, SPHINX7 | US979670...)
Affinity DataIC50:  59nMpH: 7.5 T: 2°CAssay Description:A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Exonate

LigandPNGBDBM221074(SPHINX31 | US9695160, 12 | US9796707, Compound 12)
Affinity DataIC50:  300nMpH: 7.45 T: 2°CAssay Description:Whole cell patch clamp recordings of hERG current (IhERG) were made at 37 °C from human embryonic kidney cells (HEK 293) cells stably expressing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSRSF protein kinase 1(Homo sapiens (Human))
Exonate

LigandPNGBDBM221070(SPHINX | US9695160, SPHINX | US9796707, Reference ...)
Affinity DataIC50:  880nMpH: 7.5 T: 2°CAssay Description:A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed