Compile Data Set for Download or QSAR
Report error Found 60 Enz. Inhib. hit(s) with all data for entry = 50000491
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human SphK1 expressed in baculovirus infected sf21 cells using FITC-sphingosine as substrate after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50175277(CHEMBL3809675)
Affinity DataKi:  40nMAssay Description:Inhibition of recombinant human SphK1 expressed in baculovirus infected sf9 cells using D-erythro-sphingosine as substrate in presence of [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251418(CHEMBL4075031)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251418(CHEMBL4075031)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataIC50: 360nMAssay Description:Inhibition of human recombinant C-terminal His6 tagged SphK2 expressed in baculovirus infected sf21 cells using FITC-sphingosine as substrate after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251433(CHEMBL4076550)
Affinity DataIC50: 380nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251435(CHEMBL4081791)
Affinity DataIC50: 420nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251419(CHEMBL4101713)
Affinity DataIC50: 460nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251403(CHEMBL4098301)
Affinity DataIC50: 560nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251394(CHEMBL1819205)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251435(CHEMBL4081791)
Affinity DataIC50: 670nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251419(CHEMBL4101713)
Affinity DataIC50: 670nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251434(CHEMBL4067667)
Affinity DataIC50: 710nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251433(CHEMBL4076550)
Affinity DataIC50: 780nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251394(CHEMBL1819205)
Affinity DataIC50: 820nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251434(CHEMBL4067667)
Affinity DataIC50: 840nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251408(CHEMBL4059874)
Affinity DataIC50: 880nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251430(CHEMBL4079512)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM174110((S)-2-(3-(4-octylphenyl)-1,2,4- oxadiazol-5-yl)aze...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of recombinant human SphK2 expressed in baculovirus infected sf9 cells using D-erythro-sphingosine as substrate after 20 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251423(CHEMBL4095076)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251403(CHEMBL4098301)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251401(CHEMBL4090570)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251430(CHEMBL4079512)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50600(cid_282594 | N-(3-Chloro-1,4-dioxo-1,4-dihydro-nap...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant human SphK1 using NBD-sphingosine as substrate after 2 hrs in presence of ATP by HPLC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251432(CHEMBL4062604)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251400(CHEMBL4078892)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251423(CHEMBL4095076)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251380(CHEMBL4097546)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251424(CHEMBL4102840)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251431(CHEMBL4105246)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human SphK2 using sphingosine as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251402(CHEMBL4071253)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251380(CHEMBL4097546)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251424(CHEMBL4102840)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50017016(CHEMBL3287036)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SphK1 using sphingosine as substrate in presence of [gamma-32P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM174110((S)-2-(3-(4-octylphenyl)-1,2,4- oxadiazol-5-yl)aze...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of recombinant human SphK1 expressed in baculovirus infected sf9 cells using D-erythro-sphingosine as substrate after 20 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251401(CHEMBL4090570)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Mouse)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50175277(CHEMBL3809675)
Affinity DataKi:  1.41E+4nMAssay Description:Inhibition of recombinant mouse SphK2 expressed in baculovirus infected sf9 cells using D-erythro-sphingosine as substrate in presence of [gamma-33P]...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251432(CHEMBL4062604)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50240721((E)-(2S,3R)-2-Dimethylamino-octadec-4-ene-1,3-diol...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human SphK2 expressed in baculovirus infected sf9 cells using D-erythro-sphingosine as substrate after 20 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50312869(N-aryl-4-aryl-1,3-thiazole-2-amine, 5 | CHEMBL1076...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant human SphK2 expressed in baculovirus infected sf9 cells using D-erythro-sphingosine as substrate after 20 mins in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251408(CHEMBL4059874)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50393641(CHEMBL2158686)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human SphK2 using sphingosine as substrate after 15 to 20 mins in presence of [gamma-32P]ATP by Cerenkov counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251381(CHEMBL4087389)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251395(CHEMBL4103173)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251431(CHEMBL4105246)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251426(CHEMBL4078560)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK2 (1 to 618 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251402(CHEMBL4071253)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251381(CHEMBL4087389)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50251400(CHEMBL4078892)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human SphK1 (1 to 384 residues) expressed in baculovirus expression system using sphingosine as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2019
Entry Details Article
PubMed
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