Found 91 Enz. Inhib. hit(s) with all data for entry = 50001545 TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly E4Y1 substrate after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 2.10nMAssay Description:Inhibition constant was determined against HIV-1 proteaseMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Binding affinity against sigma receptor from guinea pig brain (minus cerebellum) homogenates, using the novel [3H]-(+/-)-4 as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly E4Y1 substrate after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 7.10nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly E4Y1 substrate after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMAssay Description:Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 7.70nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly E4Y1 substrate after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition constant was determined against HIV-1 proteaseMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 7.90nMAssay Description:Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly E4Y1 substrate after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly E4Y1 substrate after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against thymidylate synthase (TS)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly E4Y1 substrate after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly E4Y1 substrate after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Antagonistic ability of angiotensin II to contract rabbit aortaMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly E4Y1 substrate after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of VEGFR2 (unknown origin) using Poly E4Y1 substrate after 1 hr by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibitory activity against thymidylate synthase (TS)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Xi'An Jiaotong University
Curated by ChEMBL
Xi'An Jiaotong University
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 74nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 87nMAssay Description:Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 87nMAssay Description:Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:The binding affinity of the compound was measured on leukotriene-6 receptor using [3H]- IL-6 as radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 93nMAssay Description:Inhibition of EPHB4 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 98nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 98nMAssay Description:Inhibition of TIE2 (unknown origin) after 4 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
