Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50000886
TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50262993BDBM50262993(CHEMBL4059711)
Affinity DataIC50: 5nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263008BDBM50263008(CHEMBL255473)
Affinity DataIC50: 6nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241259BDBM50241259(LY-411575 | (2S)-2-((S)-2-(3,5-difluorophenyl)-2-h...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50262979BDBM50262979(CHEMBL4077007)
Affinity DataIC50: 35nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263007BDBM50263007(CHEMBL4076827)
Affinity DataIC50: 44nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Mouse)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263007BDBM50263007(CHEMBL4076827)
Affinity DataIC50: 50nMAssay Description:Inhibition of SPPL2a in mouse whole blood assessed as increase in CD74/p8 accumulation after 5.5 hrs by Western bot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSimilar to RIKEN cDNA 2010106G01 (Predicted)(Rat)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263004BDBM50263004(CHEMBL4069936)
Affinity DataIC50: 56nMAssay Description:Inhibition of rat SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 77 residues) NLS as substrate after 24 hrs by Hoechst staini...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50262968BDBM50262968(CHEMBL4064631)
Affinity DataIC50: 70nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263010BDBM50263010(CHEMBL4100749)
Affinity DataIC50: 76nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263004BDBM50263004(CHEMBL4069936)
Affinity DataIC50: 77nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells using GAL4-VP16 fusedTNFalpha (1 to 76)-NTF as substrate after 24 hrs by Bright-Glo luciferase r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263004BDBM50263004(CHEMBL4069936)
Affinity DataIC50: 77nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Mouse)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263007BDBM50263007(CHEMBL4076827)
Affinity DataIC50: 97nMAssay Description:Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Mouse)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263010BDBM50263010(CHEMBL4100749)
Affinity DataIC50: 121nMAssay Description:Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Mouse)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263004BDBM50263004(CHEMBL4069936)
Affinity DataIC50: 137nMAssay Description:Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Mouse)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263004BDBM50263004(CHEMBL4069936)
Affinity DataIC50: 180nMAssay Description:Inhibition of mouse SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 77 residues) NLS as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263005BDBM50263005(CHEMBL4077336)
Affinity DataIC50: 225nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Mouse)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50262979BDBM50262979(CHEMBL4077007)
Affinity DataIC50: 370nMAssay Description:Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2B(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263004BDBM50263004(CHEMBL4069936)
Affinity DataIC50: 430nMAssay Description:Inhibition of human SPPL2b expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Mouse)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263005BDBM50263005(CHEMBL4077336)
Affinity DataIC50: 496nMAssay Description:Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Mouse)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50262979BDBM50262979(CHEMBL4077007)
Affinity DataIC50: 550nMAssay Description:Inhibition of SPPL2a in mouse whole blood assessed as increase in CD74/p8 accumulation after 5.5 hrs by Western bot methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50263006BDBM50263006(CHEMBL4074838)
Affinity DataIC50: 870nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50262965BDBM50262965(CHEMBL4105093)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50262967BDBM50262967(CHEMBL4075787)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed
TargetSignal peptide peptidase-like 2A(Human)
The Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50262966BDBM50262966(CHEMBL4086098)
Affinity DataIC50: 2.85E+3nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2020
Entry Details Article
PubMed