Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 50009263
TargetEpidermal growth factor receptor(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50453891(CHEMBL4214567)
Affinity DataIC50: 3nMAssay Description:Inhibition of human EGFR L858R/T790M mutant (696 to 1022 residues) expressed in Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50526692(CHEMBL1230881)
Affinity DataKi:  146nMAssay Description:Inhibition of wild-type human CHK1 (1 to 289 residues) expressed in baculovirus infected Sf21 insect cells preincubated for 15 mins followed by ATP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50325999(3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataIC50: 267nMAssay Description:Inhibition of wild-type BCR-ABL (unknown origin) expressed in mouse Ba/F3 cells as cell growth inhibition after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50526695(CHEMBL508280 | BI-78D3)
Affinity DataIC50: 280nMAssay Description:Inhibition of JNK1 (unknown origin) using ATF2 as substrate after 1 hr by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50431630(KRX-0401 | PERIFOSINE)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of wild-type human P38alpha MAPK expressed in Escherichia coli Rosetta cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50526693(CHEMBL4445946)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of wild-type human P38alpha MAPK expressed in Escherichia coli Rosetta cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50526696(CHEMBL4459106)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of wild-type human P38alpha MAPK expressed in Escherichia coli Rosetta cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50526694(CHEMBL4592040)
Affinity DataKd:  1.50E+3nMAssay Description:Displacement of fluorescent PIFtide from PDK1 (50 to 359 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 8(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50379277(CHEMBL90825)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of C-terminal His6-tagged human JNK1alpha1 (1 to 364 residues) expressed in Escherichia coli BL21(DE3) cells assessed as reduction in MKK7...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed