Compile Data Set for Download or QSAR
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Found 9 Enz. Inhib. hit(s) with all data for entry = 50009263
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50526692(CHEMBL1230881)
Affinity DataKi:  146nMAssay Description:Inhibition of wild-type human CHK1 (1 to 289 residues) expressed in baculovirus infected Sf21 insect cells preincubated for 15 mins followed by ATP a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50453891(CHEMBL4214567)
Affinity DataIC50:  3nMAssay Description:Inhibition of human EGFR L858R/T790M mutant (696 to 1022 residues) expressed in Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50325999(3-(6-(4-(trifluoromethoxy)phenylamino)pyrimidin-4-...)
Affinity DataIC50:  267nMAssay Description:Inhibition of wild-type BCR-ABL (unknown origin) expressed in mouse Ba/F3 cells as cell growth inhibition after 48 hrs by MTT assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50526695(BI-78D3 | CHEMBL508280)
Affinity DataIC50:  280nMAssay Description:Inhibition of JNK1 (unknown origin) using ATF2 as substrate after 1 hr by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50526696(CHEMBL4459106)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of wild-type human P38alpha MAPK expressed in Escherichia coli Rosetta cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50431630(KRX-0401 | PERIFOSINE)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of wild-type human P38alpha MAPK expressed in Escherichia coli Rosetta cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50526693(CHEMBL4445946)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of wild-type human P38alpha MAPK expressed in Escherichia coli Rosetta cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50379277(CHEMBL90825)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of C-terminal His6-tagged human JNK1alpha1 (1 to 364 residues) expressed in Escherichia coli BL21(DE3) cells assessed as reduction in MKK7...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50526694(CHEMBL4592040)
Affinity DataKd:  1.50E+3nMAssay Description:Displacement of fluorescent PIFtide from PDK1 (50 to 359 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for ...More data for this Ligand-Target Pair