Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50019573
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human CYP17A1 using progesterone as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human CYP17A1 using progesterone as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Antagonist activity at androgen receptor T877A mutant expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of an...More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human CYP17A1 using progesterone as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 103nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Antagonist activity at androgen receptor T877A mutant expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of an...More data for this Ligand-Target Pair
Affinity DataIC50: 121nMAssay Description:Antagonist activity at wild type androgen receptor expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of andro...More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 127nMAssay Description:Inhibition of recombinant human CYP17A1 using progesterone as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 209nMAssay Description:Antagonist activity at androgen receptor T877A mutant expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of an...More data for this Ligand-Target Pair
Affinity DataIC50: 235nMAssay Description:Antagonist activity at wild type androgen receptor expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of andro...More data for this Ligand-Target Pair
Affinity DataIC50: 268nMAssay Description:Antagonist activity at androgen receptor F876L mutant expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of an...More data for this Ligand-Target Pair
Affinity DataIC50: 273nMAssay Description:Antagonist activity at androgen receptor F876L mutant expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of an...More data for this Ligand-Target Pair
Affinity DataIC50: 281nMAssay Description:Antagonist activity at androgen receptor T877A mutant expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of an...More data for this Ligand-Target Pair
Affinity DataIC50: 371nMAssay Description:Antagonist activity at androgen receptor W741L mutant expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of an...More data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Antagonist activity at androgen receptor F876L mutant expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of an...More data for this Ligand-Target Pair
Affinity DataIC50: 413nMAssay Description:Antagonist activity at androgen receptor W741L mutant expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of an...More data for this Ligand-Target Pair
Affinity DataIC50: 490nMAssay Description:Antagonist activity at androgen receptor W741L mutant expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of an...More data for this Ligand-Target Pair
Affinity DataIC50: 498nMAssay Description:Antagonist activity at ERbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 522nMAssay Description:Antagonist activity at wild type androgen receptor expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of andro...More data for this Ligand-Target Pair
Affinity DataIC50: 612nMAssay Description:Antagonist activity at wild type androgen receptor expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of andro...More data for this Ligand-Target Pair
Affinity DataIC50: 810nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.03E+3nMAssay Description:Antagonist activity at androgen receptor W741L mutant expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of an...More data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam substrateMore data for this Ligand-Target Pair
Affinity DataEC50: 1.28E+3nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 1.37E+3nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 1.56E+3nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 1.68E+3nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 2.59E+3nMAssay Description:Inhibition of recombinant human CYP17A1 using progesterone as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 2.60E+3nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 2.84E+3nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 2.87E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.21E+3nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 3.31E+3nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 3.58E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.88E+3nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 4.07E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 4.76E+3nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 5.72E+3nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 6.47E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 6.58E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.44E+4nMAssay Description:Induction of androgen receptor degradation in human LNCaP cells incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 2.46E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at PR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at GR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.08E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair


3D Structure (crystal)















