Compile Data Set for Download or QSAR
Report error Found 50 Enz. Inhib. hit(s) with all data for entry = 50020993
LigandPNGBDBM50273541(N-(5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl...)
Affinity DataKd:  0.120nMAssay Description:Binding affinity to AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetFurin(Human)TBA
LigandPNGBDBM50601761(CHEMBL5203869 | US11773078, Example 263)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of furin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFurin(Human)TBA
LigandPNGBDBM50601747(CHEMBL5175553 | US11773078, Example 11)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of furin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFurin(Human)TBA
LigandPNGBDBM50601762(CHEMBL5190891 | US11773078, Example 369)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of furin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human TMPRSS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetNeuropilin-1(Human)TBA
LigandPNGBDBM50635832(CHEMBL5557974)
Affinity DataIC50: 0.598nMAssay Description:Inhibition of [125I]-VEGF-A165 binding to NRP1 (unknown origin) in HUVEC cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50635837(CHEMBL5555919)
Affinity DataKd:  0.910nMAssay Description:Binding affinity to N-terminal His-tagged human PIKfyve expressed in Sf9 cells assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProcathepsin L(Human)TBA
LigandPNGBDBM50592586(CHEMBL4852855 | US11753373, Compound C-2-b)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Cathepsin L (unknown origin) using Z-Leu-Arg-AMC as fluorogenic substrate incubated for 30 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFurin(Human)TBA
LigandPNGBDBM621498(US11773078, Example 250)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of furin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50635839(CHEMBL5557909)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PIKfyve (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFurin(Human)TBA
LigandPNGBDBM50601754(CHEMBL5208861 | US11773078, Example 207)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of furin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50429615(CHEMBL2334586)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of PIKfyve (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50424712(Camostat Mesilate | Foipan | CAMOSTAT)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human TMPRSS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50635836(CHEMBL2032358)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of N-terminal His-tagged human PIKfyve expressed in Sf9 insect cells incubated for 1 hr by enzyme assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50590929(CHEMBL4303292 | US20240016810, Compound TABLE 16.2...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of N-terminal His-tagged human PIKfyve expressed in Sf9 insect cells incubated for 1 hr by enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50590931(CHEMBL5181163)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of PIKfyve (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM557265(US11352354, Example V-c-17)
Affinity DataKd:  6.40nMAssay Description:Binding affinity to N-terminal His-tagged human PIKfyve expressed in Sf9 cells assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50635840(CHEMBL5523484)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of PIKfyve (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50021656(LY-3009104 | INCB-028050 | BARICITINIB | US1011290...)
Affinity DataKd:  8.20nMAssay Description:Binding affinity to AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50635838(CHEMBL5568317)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of PIKfyve (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFurin(Human)TBA
LigandPNGBDBM50552672(CHEMBL4790628)
Affinity DataKi:  10nMAssay Description:Binding affinity to furin (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataKd:  11nMAssay Description:Binding affinity to AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProcathepsin L(Human)TBA
LigandPNGBDBM50069985({1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 12nMAssay Description:Inhibition of Cathepsin L (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFurin(Human)TBA
LigandPNGBDBM621376(US11773078, Example 128)
Affinity DataIC50: 13nMAssay Description:Inhibition of furin (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50590927(Apilimod | Sta-5326 | STA 5326 | STA-5326 | APILIM...)
Affinity DataIC50: 14nMAssay Description:Inhibition of N-terminal His-tagged human PIKfyve expressed in Sf9 insect cells incubated for 1 hr by enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50595937(CHEMBL5194705)
Affinity DataKd:  32nMAssay Description:Binding affinity to N-terminal His-tagged human PIKfyve expressed in Sf9 cells assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50590928(CHEMBL2178735)
Affinity DataIC50: 33nMAssay Description:Inhibition of N-terminal His-tagged human PIKfyve expressed in Sf9 insect cells incubated for 1 hr by enzyme assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProcathepsin L(Human)TBA
LigandPNGBDBM50084655([(S)-1-((S)-1-Formyl-pentylcarbamoyl)-3-methyl-but...)
Affinity DataIC50: 44nMAssay Description:Inhibition of Cathepsin L (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50590930(CHEMBL5202422)
Affinity DataIC50: 61nMAssay Description:Inhibition of PIKfyve (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50635841(CHEMBL1185793)
Affinity DataIC50: 70nMAssay Description:Inhibition of human TMPRSS2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50592586(CHEMBL4852855 | US11753373, Compound C-2-b)
Affinity DataIC50: 105nMAssay Description:Inhibition of SARS-Cov-2 Main protease by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50104435(4-(6-Guanidino-hexanoyloxy)-benzoic acid ethyl est...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human TMPRSS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50590948(CHEMBL5194568)
Affinity DataIC50: 220nMAssay Description:Inhibition of PIKfyve (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50114539(Otamixaban | (2R,3R)-2-(3-Carbamimidoyl-benzyl)-3-...)
Affinity DataIC50: 620nMAssay Description:Inhibition of human TMPRSS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50311470(CHEMBL1079742 | Erlotinib | CP-358774-01 | OSI-774...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to AAK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50084952(4'-Carbamimidoyl-2'-methyl-biphenyl-4-carboxylic a...)
Affinity DataIC50: 1.24E+3nMAssay Description:Inhibition of human TMPRSS2More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50635833(TEICOPLANIN AGLYCON)
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of SARS-Cov-2 Main protease by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFurin(Human)TBA
LigandPNGBDBM50588186(CHEMBL403278 | SN-20440)
Affinity DataKi:  3.10E+3nMAssay Description:Binding affinity to furin (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFurin(Human)TBA
LigandPNGBDBM50333188(2,2'-(1,1'-(5-amino-1,3-phenylene)bis(ethan-1-yl-1...)
Affinity DataKi:  3.30E+3nMAssay Description:Binding affinity to furin (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50069985({1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of SARS-CoV-2 MPro using Dabcyl-KTSAVLQSGFRKME-Edans as substrate pre-incubated for 30 mins and measured for 15 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50069985({1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of SARS-CoV-2 MPro using Dabcyl-KTSAVLQSGFRKME-Edans as substrate pre-incubated for 45 mins and measured for 15 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProcathepsin L(Human)TBA
LigandPNGBDBM50635835(CHEMBL4744444)
Affinity DataIC50: 7.87E+3nMAssay Description:Inhibition of human Cathepsin L using Cbz-Phe-Arg-AMC as substrate measured for 10 mins by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50069985({1-[(S)-(S)-1-((S)-1-Formyl-3-methyl-butylcarbamoy...)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of SARS-CoV-2 MPro using Dabcyl-KTSAVLQSGFRKME-Edans as substrate pre-incubated for 120 mins and measured for 15 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50084655([(S)-1-((S)-1-Formyl-pentylcarbamoyl)-3-methyl-but...)
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of SARS CoV-2 main proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFurin(Human)TBA
LigandPNGBDBM50197751((2E)-2-{2-[(4-chlorobenzyl)oxy]benzylidene}hydrazi...)
Affinity DataKi:  1.18E+4nMAssay Description:Binding affinity to furin (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM557274(US11352354, Example V-c-39)
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to N-terminal His-tagged human PIKfyve expressed in Sf9 cells assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetNeuropilin-1(Human)TBA
LigandPNGBDBM50538774(CHEMBL3322197)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of [125I]-VEGF-A165 binding to NRP1 (unknown origin) in HUVEC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50635834(CHEMBL5550069)
Affinity DataIC50: 1.27E+5nMAssay Description:Inhibition of SARS-CoV-2 MPro expressed in Escherichia coli BL21 (DE3) using Dabcyl-KTSAVLQSGFRKME-Edans as substrate incubated for 1 hr by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetProcathepsin L(Human)TBA
LigandPNGBDBM50635833(TEICOPLANIN AGLYCON)
Affinity DataIC50: 2.08E+5nMAssay Description:Inhibition of human recombinant Cathepsin L using Z-Phe-Arg-AMC as substrate incubated for 60 mins by fluorescence spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFurin(Human)TBA
LigandPNGBDBM50333198(2-(1-phenylethylidene)hydrazinecarboximidamide | C...)
Affinity DataKi:  2.73E+5nMAssay Description:Binding affinity to furin (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed