Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 50021546
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataKi:  3nMAssay Description:Binding affinity to G9a (unknown origin) assessed as inhibition constant measured after 20 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50: 15nMAssay Description:Inhibition of G9a (unknown origin) using H3(1 to 25) as peptide substrate and SAM as cosubstrate measured after 20 mins by fluorescence based analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50: 15nMAssay Description:Inhibition of G9a (unknown origin) using H3(1 to 25) as peptide substrate measured after 20 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50353128(CHEMBL1231795)
Affinity DataIC50: 19nMAssay Description:Inhibition of GLP (unknown origin) using H3(1 to 25) as peptide substrate and SAM as cosubstrate measured after 20 mins by fluorescence based analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50641851(CHEMBL5569118)
Affinity DataKd:  80nMAssay Description:Binding affinity N-terminal his tagged wild type human SETDB1 (190 to 410 residues ) expressed in Escherichia coli BL21 (DE3) assessed as dissociatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50512967(CHEMBL4449143)
Affinity DataKd:  210nMAssay Description:Binding affinity N-terminal his tagged wild type human SETDB1 (190 to 410 residues ) expressed in Escherichia coli BL21 (DE3) assessed as dissociatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50641849(CHEMBL5572139)
Affinity DataKd:  232nMAssay Description:Binding affinity to SETDB1 (unknown origin) assessed as dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 700nMAssay Description:Inhibition of GLP (610 to 917 residues ) (unknown origin) expressed in Escherichia coli BL21 using H3(1 to 20)cys as substrate by spectrometry based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SUV39H1(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50315537(chaetocin | CHEMBL1089316)
Affinity DataIC50: 800nMAssay Description:Inhibition of SUV39H1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50512975(CHEMBL4471748)
Affinity DataKd:  1.60E+3nMAssay Description:Binding affinity N-terminal his tagged wild type human SETDB1 (190 to 410 residues ) expressed in Escherichia coli BL21 (DE3) assessed as dissociatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT1(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of GLP (610 to 917 residues ) (unknown origin) expressed in Escherichia coli BL21 using H3(1 to 20)cys as substrate and SAM as cosubstrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50300028(N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-meth...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of G9a (685 to 1000 residues ) (unknown origin) expressed in Escherichia coli BL21 using H3(1 to 20)cys as substrate by spectrometry based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50641848(CHEMBL5564879)
Affinity DataKd:  3.26E+3nMAssay Description:Binding affinity to SETDB1 (unknown origin) assessed as dissociation constant by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50512971(CHEMBL4471746)
Affinity DataKd:  4.40E+3nMAssay Description:Binding affinity N-terminal his tagged wild type human SETDB1 (190 to 410 residues ) expressed in Escherichia coli BL21 (DE3) assessed as dissociatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50346553(CHEMBL1797937)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of G9a (685 to 1000 residues ) (unknown origin) expressed in Escherichia coli BL21 using H3(1 to 20)cys as substrate by spectrometry based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50641850(CHEMBL5572230)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of SETDB1 (unknown origin) using histone H3 as substrate measured after 1.5 hrs by SpectraMax microplate reader analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50641851(CHEMBL5569118)
Affinity DataIC50: 7.50E+5nMAssay Description:Inhibition of GST tagged human SETDB1 (190 to 410 residues ) expressed in Escherichia coli BL21 (DE3) assessed as inhibition of H3K9me2 measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetHistone-lysine N-methyltransferase SETDB1(Human)
University of Sao Paulo

Curated by ChEMBL
LigandPNGBDBM50641851(CHEMBL5569118)
Affinity DataIC50: 9.30E+5nMAssay Description:Inhibition of GST tagged human SETDB1 (190 to 410 residues ) expressed in Escherichia coli BL21 (DE3) assessed as inhibition of H3K9me3 measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)