Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50030539
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297723BDBM50297723((4-methylpiperidin-1-yl)(6-(3-(piperidin-1-yl)prop...)
Affinity DataKi:  7nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297731BDBM50297731((6-(1-isopropylpiperidin-4-yloxy)naphthalen-2-yl)(...)
Affinity DataKi:  15nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297717BDBM50297717((6-(1-isopropylpiperidin-4-yloxy)naphthalen-2-yl)(...)
Affinity DataEC50:  17nMAssay Description:Inverse agonist activity at human histamine H3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297730BDBM50297730((4-methoxypiperidin-1-yl)(6-(3-(piperidin-1-yl)pro...)
Affinity DataKi:  30nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297734BDBM50297734((6-((1S,6S)-7-isopropyl-7-azabicyclo[4.1.1]octan-3...)
Affinity DataKi:  30nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297727BDBM50297727((6-(1-isopropylpiperidin-4-yloxy)naphthalen-2-yl)(...)
Affinity DataKi:  34nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297724BDBM50297724((6-(1-isobutylpiperidin-4-yloxy)naphthalen-2-yl)(4...)
Affinity DataKi:  36nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297717BDBM50297717((6-(1-isopropylpiperidin-4-yloxy)naphthalen-2-yl)(...)
Affinity DataKi:  40nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297716BDBM50297716((6-(1-isopropylpiperidin-4-yloxy)naphthalen-2-yl)(...)
Affinity DataKi:  62nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297722BDBM50297722(azetidin-1-yl(6-(1-isopropylpiperidin-4-yloxy)quin...)
Affinity DataKi:  62nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297733BDBM50297733((S)-1-(6-(1-isopropylpiperidin-4-yloxy)quinoline-2...)
Affinity DataKi:  87nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297729BDBM50297729((4-(hydroxymethyl)piperidin-1-yl)(6-(3-(piperidin-...)
Affinity DataKi:  103nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297721BDBM50297721(azetidin-1-yl(6-(3-(piperidin-1-yl)propoxy)quinoli...)
Affinity DataKi:  119nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297719BDBM50297719((6-(1-isopropylpiperidin-4-yloxy)quinolin-2-yl)(4-...)
Affinity DataKi:  125nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297732BDBM50297732((4-(hydroxymethyl)piperidin-1-yl)(6-(1-isopropylpi...)
Affinity DataKi:  154nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297723BDBM50297723((4-methylpiperidin-1-yl)(6-(3-(piperidin-1-yl)prop...)
Affinity DataEC50:  200nMAssay Description:Inverse agonist activity at human histamine H3 receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297726BDBM50297726((6-(1-isopropylpyrrolidin-3-yloxy)naphthalen-2-yl)...)
Affinity DataKi:  234nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297720BDBM50297720((6-(1-isopropylpiperidin-4-yloxy)quinolin-2-yl)(mo...)
Affinity DataKi:  238nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297718BDBM50297718((4-methylpiperidin-1-yl)(6-(3-(piperidin-1-yl)prop...)
Affinity DataKi:  300nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297725BDBM50297725((4-methylpiperidin-1-yl)(6-(2-(1-methylpyrrolidin-...)
Affinity DataKi:  571nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297728BDBM50297728((4-methylpiperidin-1-yl)(6-(3-morpholinopropoxy)na...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of human histamine H3 expressed in CHO cells by saturation binding experimentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297723BDBM50297723((4-methylpiperidin-1-yl)(6-(3-(piperidin-1-yl)prop...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297723BDBM50297723((4-methylpiperidin-1-yl)(6-(3-(piperidin-1-yl)prop...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297723BDBM50297723((4-methylpiperidin-1-yl)(6-(3-(piperidin-1-yl)prop...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297723BDBM50297723((4-methylpiperidin-1-yl)(6-(3-(piperidin-1-yl)prop...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297723BDBM50297723((4-methylpiperidin-1-yl)(6-(3-(piperidin-1-yl)prop...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297717BDBM50297717((6-(1-isopropylpiperidin-4-yloxy)naphthalen-2-yl)(...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297717BDBM50297717((6-(1-isopropylpiperidin-4-yloxy)naphthalen-2-yl)(...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297717BDBM50297717((6-(1-isopropylpiperidin-4-yloxy)naphthalen-2-yl)(...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297717BDBM50297717((6-(1-isopropylpiperidin-4-yloxy)naphthalen-2-yl)(...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50297717BDBM50297717((6-(1-isopropylpiperidin-4-yloxy)naphthalen-2-yl)(...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed