Compile Data Set for Download or QSAR
Report error Found 323 Enz. Inhib. hit(s) with all data for entry = 2509
TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393099BDBM50393099(CHEMBL2152914 | US10231967, Example 122 | US991898...)
Affinity DataIC50: 0.100nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 41537BDBM41537(US8865911, 114 | US10231967, Example 114 | US99189...)
Affinity DataIC50: 0.140nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 369585BDBM369585(US10231967, Example 94-Isomer-1)
Affinity DataIC50: 0.170nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393100BDBM50393100(CHEMBL2152915 | US10231967, Example 125 | US991898...)
Affinity DataIC50: 0.260nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136856BDBM136856(US8865911, 92 Isomer 2 | US10231967, Example 92-Is...)
Affinity DataIC50: 0.270nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393099BDBM50393099(CHEMBL2152914 | US10231967, Example 122 | US991898...)
Affinity DataIC50: 0.280nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393099BDBM50393099(CHEMBL2152914 | US10231967, Example 122 | US991898...)
Affinity DataIC50: 0.300nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393102BDBM50393102(US8865911, 20t | US8865911, 20t Isomer 1 | US88659...)
Affinity DataIC50: 0.360nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 369555BDBM369555(US10231967, Example 68-Isomer-1)
Affinity DataIC50: 0.380nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393100BDBM50393100(CHEMBL2152915 | US10231967, Example 125 | US991898...)
Affinity DataIC50: 0.5nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136858BDBM136858(US8865911, 94 Isomer 2 | US8865911, 94 Isomer 1 | ...)
Affinity DataIC50: 0.560nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393102BDBM50393102(US8865911, 20t | US8865911, 20t Isomer 1 | US88659...)
Affinity DataIC50: 0.560nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136739BDBM136739(US8865911, 20e | US10231967, Example 119 | US99189...)
Affinity DataIC50: 0.570nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136863BDBM136863(US8865911, 100 | US10231967, Example 100 | US99189...)
Affinity DataIC50: 0.590nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136854BDBM136854(US8865911, 91 | US10231967, Example 91 | US9918985...)
Affinity DataIC50: 0.620nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393100BDBM50393100(CHEMBL2152915 | US10231967, Example 125 | US991898...)
Affinity DataIC50: 0.630nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136761BDBM136761(US8865911, 20u | US9000182, 10 | US10231967, Examp...)
Affinity DataIC50: 0.630nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136739BDBM136739(US8865911, 20e | US10231967, Example 119 | US99189...)
Affinity DataIC50: 0.670nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 369585BDBM369585(US10231967, Example 94-Isomer-1)
Affinity DataIC50: 0.700nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 369525BDBM369525(US10231967, Example 48-Isomer-1 | US9918985, Examp...)
Affinity DataIC50: 0.700nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136863BDBM136863(US8865911, 100 | US10231967, Example 100 | US99189...)
Affinity DataIC50: 0.720nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393100BDBM50393100(CHEMBL2152915 | US10231967, Example 125 | US991898...)
Affinity DataIC50: 0.720nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393104BDBM50393104(CHEMBL2152918 | US10231967, Example 20aa | US99189...)
Affinity DataIC50: 0.720nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393106BDBM50393106(CHEMBL2152920 | US10231967, Example 72 | US9918985...)
Affinity DataIC50: 0.760nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136736BDBM136736(US8865911, 20b | US10231967, Example 20b | US99189...)
Affinity DataIC50: 0.780nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136848BDBM136848(US8865911, 85 | US10231967, Example 85 | US9918985...)
Affinity DataIC50: 0.800nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136830BDBM136830(US8865911, 68 Isomer 1 | US8865911, 67 | US1023196...)
Affinity DataIC50: 0.810nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136861BDBM136861(US8865911, 98 | US10231967, Example 98 | US9918985...)
Affinity DataIC50: 0.820nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136856BDBM136856(US8865911, 92 Isomer 2 | US10231967, Example 92-Is...)
Affinity DataIC50: 0.840nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136913BDBM136913(US8865911, 135 | US10231967, Example 135 | US99189...)
Affinity DataIC50: 0.850nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136850BDBM136850(US8865911, 87 | US10231967, Example 87 | US9918985...)
Affinity DataIC50: 0.930nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136739BDBM136739(US8865911, 20e | US10231967, Example 119 | US99189...)
Affinity DataIC50: 0.970nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136847BDBM136847(US8865911, 84 | US10231967, Example 84 | US9918985...)
Affinity DataIC50: 0.990nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136833BDBM136833(US8865911, 73 | US9000182, 21, isomer 1 | US102319...)
Affinity DataIC50: 1nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 369599BDBM369599(US10231967, Example 106 | 3-[(1r,4r)-4″-Amin...)
Affinity DataIC50: 1nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136739BDBM136739(US8865911, 20e | US10231967, Example 119 | US99189...)
Affinity DataIC50: 1.10nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136849BDBM136849(US8865911, 86 | US10231967, Example 86 | US9918985...)
Affinity DataIC50: 1.10nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 369599BDBM369599(US10231967, Example 106 | 3-[(1r,4r)-4″-Amin...)
Affinity DataIC50: 1.10nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136768BDBM136768(US8865911, 20y | US10231967, Example 20y | US99189...)
Affinity DataIC50: 1.20nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 369565BDBM369565(US10231967, Example 76-Isomer-1)
Affinity DataIC50: 1.20nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 41537BDBM41537(US8865911, 114 | US10231967, Example 114 | US99189...)
Affinity DataIC50: 1.20nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136765BDBM136765(US8865911, 20v | US10231967, Example 20v | US99189...)
Affinity DataIC50: 1.20nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 369555BDBM369555(US10231967, Example 68-Isomer-1)
Affinity DataIC50: 1.20nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136871BDBM136871(US8865911, 108 | US10231967, Example 108 | US99189...)
Affinity DataIC50: 1.30nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136833BDBM136833(US8865911, 73 | US9000182, 21, isomer 1 | US102319...)
Affinity DataIC50: 1.30nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 50393103BDBM50393103(CHEMBL2151058 | US10231967, Example 20z | US991898...)
Affinity DataIC50: 1.40nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136898BDBM136898(US8865911, 126 | US9000185, 6 | US10231967, Exampl...)
Affinity DataIC50: 1.40nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136787BDBM136787(US8865911, 30b | US10231967, Example 30c | US99189...)
Affinity DataIC50: 1.40nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 369589BDBM369589(US10231967, Example 97-Isomer-1)
Affinity DataIC50: 1.40nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetAmyloid-beta precursor protein(Human)
Astrazeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 136849BDBM136849(US8865911, 86 | US10231967, Example 86 | US9918985...)
Affinity DataIC50: 1.5nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

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