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Found 10 Enz. Inhib. hit(s) with all data for entry = 10216
TargetD(2) dopamine receptor(Homo sapiens (Human))
Neurogastrx

US Patent
LigandPNGBDBM179867(US11147820, Compound Metopimazine | US9132134, Met...)
Affinity DataKi:  0.0700nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(3) dopamine receptor(Homo sapiens (Human))
Neurogastrx

US Patent
LigandPNGBDBM179867(US11147820, Compound Metopimazine | US9132134, Met...)
Affinity DataKi:  0.610nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Neurogastrx

US Patent
LigandPNGBDBM179867(US11147820, Compound Metopimazine | US9132134, Met...)
Affinity DataKi:  1.5nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Neurogastrx

US Patent
LigandPNGBDBM179867(US11147820, Compound Metopimazine | US9132134, Met...)
Affinity DataKi:  1.90nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
Neurogastrx

US Patent
LigandPNGBDBM179867(US11147820, Compound Metopimazine | US9132134, Met...)
Affinity DataKi:  8.40nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Neurogastrx

US Patent
LigandPNGBDBM179867(US11147820, Compound Metopimazine | US9132134, Met...)
Affinity DataIC50:  2.20nMAssay Description:The functional antagonist assay was performed as described in Payne, S. L et al. (2002) J. Neurochem., 82: 1106-1117, hereby incorporated by referenc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Neurogastrx

US Patent
LigandPNGBDBM50241107(1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazo...)
Affinity DataIC50:  3.40nMAssay Description:The functional antagonist assay was performed as described in Payne, S. L et al. (2002) J. Neurochem., 82: 1106-1117, hereby incorporated by referenc...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Neurogastrx

US Patent
LigandPNGBDBM86721(BUTACLAMOL | CAS_51152-91-1 | NSC_37459 | US111478...)
Affinity DataIC50:  6.40nMAssay Description:The functional antagonist assay was performed as described in Payne, S. L et al. (2002) J. Neurochem., 82: 1106-1117, hereby incorporated by referenc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Neurogastrx

US Patent
LigandPNGBDBM48320(4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...)
Affinity DataIC50:  280nMAssay Description:The functional antagonist assay was performed as described in Payne, S. L et al. (2002) J. Neurochem., 82: 1106-1117, hereby incorporated by referenc...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Neurogastrx

US Patent
LigandPNGBDBM179868(US11147820, Compound Metopimazine acid | US9132134...)
Affinity DataIC50:  310nMAssay Description:The functional antagonist assay was performed as described in Payne, S. L et al. (2002) J. Neurochem., 82: 1106-1117, hereby incorporated by referenc...More data for this Ligand-Target Pair
In DepthDetails US Patent