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Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM50499292
Substrate
n/a
Meas. Tech.
ChEMBL_1538840 (CHEMBL3737415)
IC50
4.0±n/a nM
Citation
Imbriglio, JE; Shen, DM; Liang, R; Marby, K; You, M; Youm, HW; Feng, Z; London, C; Xiong, Y; Tata, J; Verras, A; Garcia-Calvo, M; Song, X; Addona, GH; McLaren, DG; He, T; Murphy, B; Metzger, DE; Salituro, G; Deckman, D; Chen, Q; Jin, X; Stout, SJ; Wang, SP; Wilsie, L; Palyha, O; Han, S; Hubbard, BK; Previs, SF; Pinto, S; Taggart, A Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors. J Med Chem 58:9345-53 (2015) [PubMed] Article
More Info.:
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Human
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN