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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50499952
Substrate
n/a
Meas. Tech.
ChEMBL_1541019 (CHEMBL3744250)
Ki
39±n/a nM
Citation
 Blanco, MJ; Vetman, T; Chandrasekhar, S; Fisher, MJ; Harvey, A; Mudra, D; Wang, XS; Yu, XP; Schiffler, MA; Warshawsky, AM Discovery of substituted-2,4-dimethyl-(naphthalene-4-carbonyl)amino-benzoic acid as potent and selective EP4 antagonists. Bioorg Med Chem Lett 26:105-9 (2016) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50499952
Synonyms:
CHEMBL3741642
Type:
Small organic molecule
Emp. Form.:
C25H20N2O3
Mol. Mass.:
396.4379
SMILES:
Cc1cc(cc(C)c1NC(=O)c1cc(nc2ccccc12)-c1ccccc1)C(O)=O
Structure:
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