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Found 1685 with Last Name = 'harvey' and Initial = 'a'
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140256(CHEMBL3740223)
Affinity DataKi:  2nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50140258(CHEMBL3740325)
Affinity DataKi:  3.5nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50499955(CHEMBL3741430)
Affinity DataKi:  3.5nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50319936((1S,4S)-2-methyl-5-(6-phenylpyridazin-3-yl)-2,5-di...)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]epibatidine from rat alpha7 nAChR transfected in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50499950(CHEMBL3739435)
Affinity DataKi:  6.70nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50499949(CHEMBL3742015)
Affinity DataKi:  8nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206172(1-(benzo[d][1,3]dioxol-5-ylmethyl)-2,3,4,9-tetrahy...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50499954(CHEMBL3741902)
Affinity DataKi:  17nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206189(1-(2-(propylthio)benzyl)-2,3,4,9-tetrahydro-1H-pyr...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206163(1-(3-Methoxy-benzyl)-2,3,4,9-tetrahydro-1H-beta-ca...)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50082084(CHEMBL3422597)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]epibatidine from rat alpha7 nAChR transfected in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206164(1-(2-(methylthio)benzyl)-2,3,4,9-tetrahydro-1H-pyr...)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206169(1-(benzo[d][1,3]dioxol-5-ylmethyl)-6-methoxy-2,3,4...)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50499952(CHEMBL3741642)
Affinity DataKi:  39nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50107278(CHEMBL3600884)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50107280(CHEMBL3600788)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206175(1-(3-methoxybenzyl)-6-methoxy-2,3,4,9-tetrahydro-1...)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206186(2-fluoro-6-((2,3,4,9-tetrahydro-1H-pyrido[3,4-b]in...)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50499953(CHEMBL3739779)
Affinity DataKi:  52nMAssay Description:Antagonist activity at human EP4 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM142234(US8933098, 1 | US8933099, 1)
Affinity DataKi:  58nMAssay Description:Binding affinity to human EP4More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Institute Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM21190(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]ZM-241385 from human cloned adenosine A2A receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50257823(CHEMBL4089551)
Affinity DataKi:  80nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged IKKalpha (1 to 745 residues) expressed in baculovirus expression system using biotinylated IkBa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206168(2,9-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibe...)
Affinity DataKi:  80nMAssay Description:Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50082081(CHEMBL3422581)
Affinity DataKi:  85nMAssay Description:Displacement of [3H]epibatidine from rat alpha7 nAChR transfected in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Institute Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  95nMAssay Description:Displacement of [3H]DPCPX from human cloned adenosine A1 receptor expressed in CHOK1 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206183((E)-6-((benzyl(methyl)amino)methyleneamino)-2,3-di...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Institute Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50279446(8-[3-(2-Diethylaminoethoxy)phenyl]-1,3-dimethylxan...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]ZM-241385 from human cloned adenosine A2A receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Institute Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50279444(1,3-Dimethyl-8-[4-methoxy-3-(2-morpholin-4-ylethox...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]ZM-241385 from human cloned adenosine A2A receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50257884(CHEMBL4065551)
Affinity DataKi:  100nMAssay Description:Inhibition of recombinant full length human IKKbeta expressed in baculovirus infected sf9 insect cells using biotinylated IkBalpha as substrate after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206178((E)-6-((3,4-dihydroisoquinolin-2(1H)-yl)methylenea...)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50104175((S)-2-Oxo-4-phenyl-3-(4-phenylazo-benzoylamino)-bu...)
Affinity DataKi:  110nMAssay Description:Difference between inhibition of alpha-chymotrypsin by the UV light and inhibition of alpha-chymotrypsin by the ambient lightMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50107282(CHEMBL3600786)
Affinity DataKi:  126nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50107281(CHEMBL3600787)
Affinity DataKi:  129nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Institute Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  130nMAssay Description:Displacement of [3H]ZM-241385 from human cloned adenosine A2A receptor expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50104175((S)-2-Oxo-4-phenyl-3-(4-phenylazo-benzoylamino)-bu...)
Affinity DataKi:  130nMAssay Description:Inhibition constant for inhibition of alpha-chymotrypsin by the UV lightMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50082083(CHEMBL3422596)
Affinity DataKi:  140nMAssay Description:Displacement of [3H]epibatidine from rat alpha7 nAChR transfected in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206161(1-(4-(methylthio)benzyl)-2,3,4,9-tetrahydro-1H-pyr...)
Affinity DataKi:  170nMAssay Description:Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50082085(CHEMBL3422567)
Affinity DataKi:  190nMAssay Description:Displacement of [3H]epibatidine from rat alpha7 nAChR transfected in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206165((E)-7-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]N-methylscopolamine from muscarinic M4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206173((E)-7-((3,4-dihydroisoquinolin-2(1H)-yl)methylenea...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206190((E)-3-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]N-methylscopolamine from muscarinic M4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206162((E)-N-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206174((E)-6-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]N-methylscopolamine from muscarinic M4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50300803(5-(piperidin-1-yl)-N-(4-(pyridin-3-yl)phenyl)penta...)
Affinity DataKi:  220nMAssay Description:Displacement of [3H]epibatidine from rat alpha7 nAChR transfected in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50104175((S)-2-Oxo-4-phenyl-3-(4-phenylazo-benzoylamino)-bu...)
Affinity DataKi:  240nMAssay Description:Inhibition constant for inhibition of alpha-chymotrypsin by the UV lightMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50104174((S)-2-Oxo-4-phenyl-3-(4-phenylazo-benzyloxycarbony...)
Affinity DataKi:  290nMAssay Description:Inhibition constant for inhibition of alpha-chymotrypsin by the ambient lightMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206192((E)-6-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)...)
Affinity DataKi:  300nMAssay Description:Displacement of [3H]N-methylscopolamine from muscarinic M4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206184((E)-N-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)...)
Affinity DataKi:  300nMAssay Description:Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
University Of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50206162((E)-N-((6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)...)
Affinity DataKi:  300nMAssay Description:Displacement of [3H]N-methylscopolamine from muscarinic M4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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