Reaction Details Report a problem with these data
Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM50577404
Substrate
n/a
Meas. Tech.
ChEMBL_2130034 (CHEMBL4839463)
IC50
17±n/a nM
Citation
 Di Fruscia, P; Carbone, A; Bottegoni, G; Berti, F; Giacomina, F; Ponzano, S; Pagliuca, C; Fiasella, A; Pizzirani, D; Ortega, JA; Nuzzi, A; Tarozzo, G; Mengatto, L; Giampà, R; Penna, I; Russo, D; Romeo, E; Summa, M; Bertorelli, R; Armirotti, A; Bertozzi, SM; Reggiani, A; Bandiera, T; Bertozzi, F Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent  J Med Chem 64:13327-13355 (2021) [PubMed]  Article 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Human
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
  
Inhibitor
Name:
BDBM50577404
Synonyms:
CHEMBL4864438
Type:
Small organic molecule
Emp. Form.:
C20H29N5O3S
Mol. Mass.:
419.541
SMILES:
[H][C@]12CC[C@]([H])(C[C@@H](C1)Oc1cnc(CCCC)cn1)N2S(=O)(=O)c1c(C)n[nH]c1C |r,TLB:9:7:20:2.3|
Structure:
Search PDB for entries with ligand similarity: