Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50152161
Substrate
n/a
Meas. Tech.
ChEMBL_303525 (CHEMBL839639)
Ki
20±n/a nM
Citation
 Chen, C; Wilcoxen, KM; Huang, CQ; Xie, YF; McCarthy, JR; Webb, TR; Zhu, YF; Saunders, J; Liu, XJ; Chen, TK; Bozigian, H; Grigoriadis, DE Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists. J Med Chem 47:4787-98 (2004) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50152161
Synonyms:
CHEMBL364828 | [3-(6-Dimethylamino-2,4-dimethyl-pyridin-3-yl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine
Type:
Small organic molecule
Emp. Form.:
C22H32N6
Mol. Mass.:
380.5297
SMILES:
CCCN(CCC)c1cc(C)nc2c(cnn12)-c1c(C)cc(nc1C)N(C)C |(3.92,5.72,;4.4,4.25,;3.38,3.12,;3.87,1.65,;5.38,1.35,;6.4,2.49,;7.89,2.19,;2.84,.51,;3.33,-.94,;2.31,-2.1,;2.79,-3.55,;.82,-1.77,;.33,-.33,;-1.07,.3,;-.93,1.84,;.59,2.16,;1.35,.82,;-2.39,-.47,;-3.73,.29,;-3.75,1.84,;-5.07,-.47,;-5.07,-2.03,;-3.73,-2.79,;-2.39,-2.03,;-1.07,-2.79,;-6.4,-2.79,;-7.75,-2.03,;-6.4,-4.33,)|
Structure:
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