Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50152175
Substrate
n/a
Meas. Tech.
ChEMBL_303525 (CHEMBL839639)
Ki
260±n/a nM
Citation
 Chen, C; Wilcoxen, KM; Huang, CQ; Xie, YF; McCarthy, JR; Webb, TR; Zhu, YF; Saunders, J; Liu, XJ; Chen, TK; Bozigian, H; Grigoriadis, DE Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists. J Med Chem 47:4787-98 (2004) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50152175
Synonyms:
CHEMBL184284 | [3-(6-Dimethylamino-4-methyl-pyridin-3-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-(1-methoxymethyl-propyl)-amine
Type:
Small organic molecule
Emp. Form.:
C21H30N6O
Mol. Mass.:
382.5025
SMILES:
CCC(COC)Nc1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(1.7,4.5,;2.19,3.03,;3.69,2.72,;4.72,3.89,;6.23,3.56,;7.24,4.71,;4.18,1.25,;3.16,.11,;3.62,-1.34,;2.61,-2.5,;3.09,-3.95,;1.12,-2.18,;.63,-.73,;-.79,-.1,;-.62,1.44,;-1.79,2.44,;.89,1.77,;1.64,.41,;-2.1,-.87,;-2.1,-2.43,;-3.45,-3.2,;-4.78,-2.43,;-4.78,-.89,;-3.45,-.1,;-3.45,1.44,;-6.11,-3.2,;-7.44,-2.43,;-6.11,-4.74,)|
Structure:
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