Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50152184
Substrate
n/a
Meas. Tech.
ChEMBL_303525 (CHEMBL839639)
Ki
13±n/a nM
Citation
 Chen, C; Wilcoxen, KM; Huang, CQ; Xie, YF; McCarthy, JR; Webb, TR; Zhu, YF; Saunders, J; Liu, XJ; Chen, TK; Bozigian, H; Grigoriadis, DE Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists. J Med Chem 47:4787-98 (2004) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50152184
Synonyms:
CHEMBL189754 | [3-(6-Dimethylamino-4-methyl-pyridin-3-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-(1,4-dimethyl-pentyl)-amine
Type:
Small organic molecule
Emp. Form.:
C23H34N6
Mol. Mass.:
394.5563
SMILES:
CC(C)CCC(C)Nc1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(8.29,4.19,;6.77,4.5,;6.3,5.97,;5.75,3.35,;4.25,3.68,;3.23,2.51,;1.71,2.82,;3.71,1.05,;2.68,-.1,;3.16,-1.55,;2.13,-2.71,;2.62,-4.16,;.64,-2.39,;.15,-.93,;-1.25,-.31,;-1.1,1.23,;-2.26,2.24,;.4,1.56,;1.17,.2,;-2.58,-1.08,;-2.58,-2.64,;-3.91,-3.41,;-5.24,-2.64,;-5.24,-1.1,;-3.91,-.31,;-3.92,1.23,;-6.58,-3.41,;-6.58,-4.95,;-7.93,-2.64,)|
Structure:
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