Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50591851
Substrate
n/a
Meas. Tech.
ChEMBL_2202276 (CHEMBL5114984)
IC50
9700±n/a nM
Citation
Federico, S; Khan, T; Fontana, A; Brogi, S; Benedetti, R; Sarno, F; Carullo, G; Pezzotta, A; Saraswati, AP; Passaro, E; Pozzetti, L; Papa, A; Relitti, N; Gemma, S; Butini, S; Pistocchi, A; Ramunno, A; Vincenzi, F; Varani, K; Tatangelo, V; Patrussi, L; Baldari, CT; Saponara, S; Gorelli, B; Lamponi, S; Valoti, M; Saccoccia, F; Giannaccari, M; Ruberti, G; Herp, D; Jung, M; Altucci, L; Campiani, G Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability. Eur J Med Chem 238:0 (2022) [PubMed]
More Info.:
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA