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Target
Polyamine deacetylase HDAC10
Ligand
BDBM50591852
Substrate
n/a
Meas. Tech.
ChEMBL_2202279 (CHEMBL5114987)
IC50
6500±n/a nM
Citation
 Federico, S; Khan, T; Fontana, A; Brogi, S; Benedetti, R; Sarno, F; Carullo, G; Pezzotta, A; Saraswati, AP; Passaro, E; Pozzetti, L; Papa, A; Relitti, N; Gemma, S; Butini, S; Pistocchi, A; Ramunno, A; Vincenzi, F; Varani, K; Tatangelo, V; Patrussi, L; Baldari, CT; Saponara, S; Gorelli, B; Lamponi, S; Valoti, M; Saccoccia, F; Giannaccari, M; Ruberti, G; Herp, D; Jung, M; Altucci, L; Campiani, G Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability. Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
Polyamine deacetylase HDAC10
Synonyms:
HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
71431.89
Organism:
Homo sapiens (Human)
Description:
Q969S8
Residue:
669
Sequence:
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA
  
Inhibitor
Name:
BDBM50591852
Synonyms:
CHEMBL5188540
Type:
Small organic molecule
Emp. Form.:
C29H30N4O4
Mol. Mass.:
498.5729
SMILES:
ONC(=O)c1ccc(CNC(=O)N2CCC(CC2)N2CC(C2=O)(c2ccccc2)c2ccccc2)cc1
Structure:
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