Reaction Details Report a problem with these data
Target
Histone deacetylase 2b
Ligand
BDBM50234054
Substrate
n/a
Meas. Tech.
ChEMBL_322291 (CHEMBL885046)
IC50
12±n/a nM
Citation
Mai, A; Massa, S; Rotili, D; Pezzi, R; Bottoni, P; Scatena, R; Meraner, J; Brosch, G Exploring the connection unit in the HDAC inhibitor pharmacophore model: novel uracil-based hydroxamates. Bioorg Med Chem Lett 15:4656-61 (2005) [PubMed] Article
More Info.:
Target
Name:
Histone deacetylase 2b
Synonyms:
Histone deacetylase HD2
Type:
PROTEIN
Mol. Mass.:
30785.07
Organism:
Maize
Description:
ChEMBL_87549
Residue:
286
Sequence:
MEVGGQEVKPGATVSCKVGDGLVIHLSQAALGESKKASENAILSVNIDDKKLVLGTLSVEKHPQISCDLVFDKDFELPHNSKTRSVFFRGYKSPVPLFESNSGEDSSDEELKTDQIPLQNNEIKISAAKVPAKDDDDDVFIILAMMMMIYSSDDDDDDFTTSDSDNEMSEEDDSSDEDEMSEEDDSSDEDEMSGGADPSDDSSDESGSEHTSAPKKTDVVVGKKRAIKAEAPYGKKAKSEQSSQKTGDKASTSHPAKQSIKTPADKSRKTPTADKKSPKSGSHGCK
Inhibitor
Name:
BDBM50234054
Synonyms:
6-(6-Oxo-4-phenyl-1,6-dihydro-pyrimidin-2-ylsulfanyl)-hexanoic acid hydroxyamide | CHEMBL261831 | N-hydroxy-6-(3,4-dihydro-4-oxo-6-phenyl-2-pyrimidinylthio)hexanamide | N-hydroxy-6-(6-oxo-4-phenyl-1,6-dihydropyrimidin-2-ylthio)hexanamide
Type:
Small organic molecule
Emp. Form.:
C16H19N3O3S
Mol. Mass.:
333.405
SMILES:
ONC(=O)CCCCCSc1nc(cc(=O)[nH]1)-c1ccccc1