Reaction Details Report a problem with these data
Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50285675
Substrate
n/a
Meas. Tech.
ChEMBL_99994 (CHEMBL710519)
IC50
0.65±n/a nM
Citation
Labelle, M; Gareau, Y; Dufresne, C; Lau, CK; Belley, M; Jones, TR; Leblanc, Y; McAuliffe, M; McFarlane, CS; Metters, KM; Ouimet, N; Perrier, H; Rochette, C; Sawyer, N; Slipetz, D; Xiang, YB; Wang, Z; Pickett, CB; Ford-Hutchinson, AW; Young, RN Discovery of L-740,515, a potent thienopyridine cysLT1 receptor (LTD4 receptor) antagonist Bioorg Med Chem Lett 5:2551-2556 (1995) Article
More Info.:
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38565.16
Organism:
Homo sapiens (Human)
Description:
Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271
Residue:
337
Sequence:
MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQVYMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDNQTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTAAFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
Inhibitor
Name:
BDBM50285675
Synonyms:
(1-{(R)-1-{3-[(E)-2-(2,3-Dichloro-thieno[3,2-b]pyridin-5-yl)-vinyl]-phenyl}-3-[4-(1-hydroxy-cyclobutyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid | CHEMBL414885
Type:
Small organic molecule
Emp. Form.:
C34H33Cl2NO3S2
Mol. Mass.:
638.667
SMILES:
OC(=O)CC1(CS[C@H](CCc2ccc(cc2)C2(O)CCC2)c2cccc(\C=C\c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1