Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM50336951
Substrate
n/a
Meas. Tech.
ChEMBL_718609 (CHEMBL1680635)
EC50
42±n/a nM
Citation
Lanman, BA; Cee, VJ; Cheruku, SR; Frohn, M; Golden, J; Lin, J; Lobera, M; Marantz, Y; Muller, KM; Neira, SC; Pickrell, AJ; Rivenzon-Segal, D; Schutz, N; Sharadendu, A; Yu, X; Zhang, Z; Buys, J; Fiorino, M; Gore, A; Horner, M; Itano, A; McElvain, M; Middleton, S; Schrag, M; Vargas, HM; Xu, H; Xu, Y; Zhang, X; Siu, J Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1) ACS Med Chem Lett 2:102-106 (2011) [PubMed] Article
More Info.:
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Human
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
Inhibitor
Name:
BDBM50336951
Synonyms:
1-((4-(5-(2,4-Difluorobenzyl)benzo[d]thiazol-2-yl)-3-fluorophenyl)methyl)azetidine-3-carboxylic acid | CHEMBL1672561
Type:
Small organic molecule
Emp. Form.:
C25H19F3N2O2S
Mol. Mass.:
468.491
SMILES:
OC(=O)C1CN(Cc2ccc(-c3nc4cc(Cc5ccc(F)cc5F)ccc4s3)c(F)c2)C1