Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM50383265
Substrate
n/a
Meas. Tech.
ChEMBL_819566 (CHEMBL2033650)
Ki
11±n/a nM
Citation
 Good, AC; Liu, J; Hirth, B; Asmussen, G; Xiang, Y; Biemann, HP; Bishop, KA; Fremgen, T; Fitzgerald, M; Gladysheva, T; Jain, A; Jancsics, K; Metz, M; Papoulis, A; Skerlj, R; Stepp, JD; Wei, RR Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J Med Chem 55:2641-8 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Human
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM50383265
Synonyms:
CHEMBL2032368
Type:
Small organic molecule
Emp. Form.:
C18H18F3N5
Mol. Mass.:
361.3642
SMILES:
FC(F)(F)c1ccc(cc1)-c1nnc2ccc(NC3CCCCC3)nn12
Structure:
Search PDB for entries with ligand similarity: