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Found 185 with Last Name = 'asmussen' and Initial = 'g'
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]CFT from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]dopamine from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]dopamine from human NET expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50383265(CHEMBL2032368)
Affinity DataKi:  11nMAssay Description:Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50101075((2S,3S)-3-(3,4-Dichloro-phenyl)-2-methoxycarbonyl-...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]5HT from human SERT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]CFT from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177766(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]CFT from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177769(CHEMBL198842 | [1-(3-{2-[3-(3,4-Dichloro-phenyl)-2...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]CFT from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  62nMAssay Description:Displacement of [3H]dopamine from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177766(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  72nMAssay Description:Displacement of [3H]dopamine from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177766(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  177nMAssay Description:Displacement of [3H]dopamine from human NET expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  194nMAssay Description:Displacement of [3H]dopamine from human NET expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177769(CHEMBL198842 | [1-(3-{2-[3-(3,4-Dichloro-phenyl)-2...)
Affinity DataKi:  227nMAssay Description:Displacement of [3H]5HT from human SERT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177769(CHEMBL198842 | [1-(3-{2-[3-(3,4-Dichloro-phenyl)-2...)
Affinity DataKi:  250nMAssay Description:Displacement of [3H]dopamine from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177769(CHEMBL198842 | [1-(3-{2-[3-(3,4-Dichloro-phenyl)-2...)
Affinity DataKi:  308nMAssay Description:Displacement of [3H]dopamine from human NET expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177767(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  392nMAssay Description:Displacement of [3H]5HT from human SERT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177768(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  436nMAssay Description:Displacement of [3H]dopamine from human DAT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177768(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  627nMAssay Description:Displacement of [3H]dopamine from human NET expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177768(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  705nMAssay Description:Displacement of [3H]5HT from human SERT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50177766(2-(3-sec-Butylimino-6-diethylamino-3H-xanthen-9-yl...)
Affinity DataKi:  1.49E+3nMAssay Description:Displacement of [3H]5HT from human SERT expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50383272(CHEMBL2032375)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323215((2S,3S)-N-((S)-1-(4-(5-(2-cyclohexylethyl)-1,2,4-o...)
Affinity DataIC50:  10nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345260(CHEMBL1782531 | trans-7-(4-aminocyclohexylamino)-5...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345250(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323216((2S,3S)-N-((S)-1-(4-(5-(2-cyclohexylethyl)-1,2,4-o...)
Affinity DataIC50:  20nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345245(CHEMBL1782516 | trans-5-(6-(4-(aminomethyl)cyclohe...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM26626((5Z)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323223((2S,3S)-N-(4-(5-(2-cyclohexylethyl)-1,2,4-oxadiazo...)
Affinity DataIC50:  25nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323219((2S,3S)-N-((S)-1-(4-(5-heptyl-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345253(5-bromo-7-(2-(piperidin-4-yl)ethylamino)benzofuran...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323220((2S,3S)-N-((S)-1-(4-(5-heptyl-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  48nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323231((2S,3S)-N-(4-(5-hexyl-1,2,4-oxadiazol-3-yl)benzyl)...)
Affinity DataIC50:  49nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50299323((S)-2-amino-4-hydroxy-N-(4-octylphenyl)butanamide ...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human sphingosine kinase 1 by off chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50209188(6-(2-Hydroxy-phenyl)-2-oxo-4-phenyl-1,2-dihydro-py...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345251(5-bromo-7-(2-(piperidin-4-yl)ethoxy)benzofuran-2-c...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345245(CHEMBL1782516 | trans-5-(6-(4-(aminomethyl)cyclohe...)
Affinity DataIC50:  53nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345242(CHEMBL1782513 | trans-5-(6-(4-aminocyclohexylamino...)
Affinity DataIC50:  54nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345255(5-bromo-7-(2-(piperidin-4-yl)acetamido)benzofuran-...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323242((2S,3S)-N-((S)-1-(4-(5-(2-cyclopentylethyl)-1,2,4-...)
Affinity DataIC50:  56nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM28394((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323217((2S,3S)-N-((S)-1-(4-(5-(2-cyclopentylethyl)-1,2,4-...)
Affinity DataIC50:  58nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345247(5-bromo-7-(piperidin-4-ylmethoxy)benzofuran-2-carb...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323234((2S,3S)-N-(4-(3-heptyl-1,2,4-oxadiazol-5-yl)benzyl...)
Affinity DataIC50:  61nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50299328((2S,3S)-3-hydroxy-N-(4-octylphenyl)pyrrolidine-2-c...)
Affinity DataIC50:  62nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50299328((2S,3S)-3-hydroxy-N-(4-octylphenyl)pyrrolidine-2-c...)
Affinity DataIC50:  62nMAssay Description:Inhibition of human sphingosine kinase 1 by off chip mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345260(CHEMBL1782531 | trans-7-(4-aminocyclohexylamino)-5...)
Affinity DataIC50:  66nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323240((2S,3S)-N-(4-(5-heptyl-1,2,4-oxadiazol-3-yl)benzyl...)
Affinity DataIC50:  68nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50323225((2S,3S)-N-(4-(5-(2-cyclopentylethyl)-1,2,4-oxadiaz...)
Affinity DataIC50:  68nMAssay Description:Inhibition of sphingosine kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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